Version 1
: Received: 23 October 2019 / Approved: 24 October 2019 / Online: 24 October 2019 (15:48:02 CEST)
How to cite:
Méndez-Sánchez, N.; Coronel-Castillo, C. E.; Contreras-Carmona, J.; Barranco-Fragoso, B.; Qi, X. The Cellular Pathways of Liver Fibrosis in NASH. Preprints2019, 2019100282. https://doi.org/10.20944/preprints201910.0282.v1
Méndez-Sánchez, N.; Coronel-Castillo, C. E.; Contreras-Carmona, J.; Barranco-Fragoso, B.; Qi, X. The Cellular Pathways of Liver Fibrosis in NASH. Preprints 2019, 2019100282. https://doi.org/10.20944/preprints201910.0282.v1
Méndez-Sánchez, N.; Coronel-Castillo, C. E.; Contreras-Carmona, J.; Barranco-Fragoso, B.; Qi, X. The Cellular Pathways of Liver Fibrosis in NASH. Preprints2019, 2019100282. https://doi.org/10.20944/preprints201910.0282.v1
APA Style
Méndez-Sánchez, N., Coronel-Castillo, C. E., Contreras-Carmona, J., Barranco-Fragoso, B., & Qi, X. (2019). The Cellular Pathways of Liver Fibrosis in NASH. Preprints. https://doi.org/10.20944/preprints201910.0282.v1
Chicago/Turabian Style
Méndez-Sánchez, N., Beatriz Barranco-Fragoso and Xingshun Qi. 2019 "The Cellular Pathways of Liver Fibrosis in NASH" Preprints. https://doi.org/10.20944/preprints201910.0282.v1
Abstract
Nonalcoholic steatohepatitis (NASH), which is characterized by liver steatosis, inflammation and fibrosis, is the most severe variation of nonalcoholic fatty liver disease (NAFLD). This disease is a consequence of several metabolic alterations such as type 2 diabetes and dyslipidemia that trigger different pathways of cell dysfunction and systemic inflammation which ultimately affect the liver. Furthermore, those mechanisms activate a complex cascade of immune response after repeated cell aggression. In the liver cytokines and interleukins interact with network of innate immune cells, including Kupffer cells (KCs), dendritic cells (DCs), lymphocytes and hepatic stellate cells (HSC). These cells translate those signals into immune responses and pathologic hepatic changes during the development of NASH. In this scenario the development of fibrosis is the most important change since it is an adaptive mechanism that in the short time has the objective of repair the damaged tissue but after prolonged injury it progresses to parenchymal scarring, cellular dysfunction and finally to organ failure. Finally, since NASH is an important cause of liver cirrhosis; this review addresses the cellular pathways of fibrosis in the setting of NASH explained by the interaction between immune and hepatic cells.
Keywords
liver fibrosis; NASH; innate immune cells.
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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