Preprint Short Note Version 1 This version is not peer-reviewed

Calcium, Actomyosin Kinetics, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy

Version 1 : Received: 4 October 2019 / Approved: 7 October 2019 / Online: 7 October 2019 (12:12:35 CEST)

How to cite: Smith, G.A. Calcium, Actomyosin Kinetics, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy. Preprints 2019, 2019100067 (doi: 10.20944/preprints201910.0067.v1). Smith, G.A. Calcium, Actomyosin Kinetics, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy. Preprints 2019, 2019100067 (doi: 10.20944/preprints201910.0067.v1).

Abstract

In an attempt to correct misunderstandings this article brings together the observations on Calcium, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy in the basic function of cardiac muscle. A finding of many years ago is reiterated in a novel enzyme kinetic format with defined rate limiting step which makes CaATP the apparent substrate of the actomyosin cross-bridge. The relationship of these kinetics to recent observations on disruption of myosin binding protein-C is described along with how this bears on the understanding of the related cardiomyopathies.

Subject Areas

Calcium; Actomyosin Kinetics; Myosin Binding Protein-C; Hypertrophic Cardiomyopathy

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