Preprint Short Note Version 1 Preserved in Portico This version is not peer-reviewed

Calcium, Actomyosin Kinetics, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy

Version 1 : Received: 4 October 2019 / Approved: 7 October 2019 / Online: 7 October 2019 (12:12:35 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Journal of Integrative Cardiology, ISSN: 2058-3702 2019, 5, 1-2
DOI: 10.15761/JIC.1000277


In an attempt to correct misunderstandings this article brings together the observations on Calcium, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy in the basic function of cardiac muscle. A finding of many years ago is reiterated in a novel enzyme kinetic format with defined rate limiting step which makes CaATP the apparent substrate of the actomyosin cross-bridge. The relationship of these kinetics to recent observations on disruption of myosin binding protein-C is described along with how this bears on the understanding of the related cardiomyopathies.


Calcium; Actomyosin Kinetics; Myosin Binding Protein-C; Hypertrophic Cardiomyopathy


LIFE SCIENCES, Biochemistry

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0

Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.