Preprint Article Version 1 This version is not peer-reviewed

Acids Can Promote the Onset and Multimorbidity of Allergic and Nonallergic Airway Diseases

Version 1 : Received: 4 June 2019 / Approved: 5 June 2019 / Online: 5 June 2019 (10:42:43 CEST)

How to cite: Molinari, G.; Molinari, L.; Nervo, E. Acids Can Promote the Onset and Multimorbidity of Allergic and Nonallergic Airway Diseases. Preprints 2019, 2019060040 (doi: 10.20944/preprints201906.0040.v1). Molinari, G.; Molinari, L.; Nervo, E. Acids Can Promote the Onset and Multimorbidity of Allergic and Nonallergic Airway Diseases. Preprints 2019, 2019060040 (doi: 10.20944/preprints201906.0040.v1).

Abstract

Inflammatory allergic and nonallergic respiratory pathologies often co-exist. The root cause is not clear. This paper demonstrates that it is ascribable to protons (H+) released into cells by exogenous and endogenous acids. The hypothesis of acids as the common cause stems from two considerations: a) it has long been known that exogenous acids present in air pollutants can induce the irritation of epithelial surfaces, particularly the airways, inflammation and bronchospasm; b) according to recent articles, endogenous acids, generated in cells by phospholipases, play a key role in the biochemical mechanisms of initiation and progression of allergic responses. Therefore, the intracellular acidification and consequent Ca2+ increase, induced by protons generated by either acid pollutants or endogenous phospholipases, may be the causal mechanism of the multimorbidity of these diseases, and environmental acidity may contribute to their spread.

Subject Areas

acid, air pollution, allergic diseases, Ca2+, mechanisms of allergy, multimorbidity, nonallergic, nonatopic

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