Preprint Article Version 1 This version is not peer-reviewed

Circulating 25-Hydroxyviamin D Levels and Risk of Incident Stroke: An Updated Meta-Analysis

Version 1 : Received: 10 May 2019 / Approved: 13 May 2019 / Online: 13 May 2019 (10:16:48 CEST)

How to cite: Bae, J. Circulating 25-Hydroxyviamin D Levels and Risk of Incident Stroke: An Updated Meta-Analysis. Preprints 2019, 2019050153 (doi: 10.20944/preprints201905.0153.v1). Bae, J. Circulating 25-Hydroxyviamin D Levels and Risk of Incident Stroke: An Updated Meta-Analysis. Preprints 2019, 2019050153 (doi: 10.20944/preprints201905.0153.v1).

Abstract

A recent systematic review for 19 selected articles after searching through to 30 September 2017 showed vitamin D deficiency was associated with ischemic stroke (IS), not hemorrhagic stroke (HS). But a heterogeneity would be introduced with comparing the lowest and highest category of vitamin D. The aim of this article was to conduct an updated meta-analysis (UMA) with searching through to 31 March 2019. An interval collapsing method as information extraction was applied in order to decrease a heterogeneity among studies. Additional articles were selected from cited lists from 19 selected articles using citation discovery tools. Random effect model was applied if I-squared value was over 50%. A funnel plot and Egger’s test were used to detect a publication bias. After 5 new studies were added, the summary RRs [and their 95% confidence intervals] (I-squared value) were 1.52 [1.33–1.74] (0.0%) in IS, and 2.44 [1.34–4.46] (69.7%) in HS. This UMA supported the hypothesis that serum vitamin D deficiency was associated with an increased risk of HS as well as IS. Diverse public health programs against vitamin D deficiency status would be needed for higher risk group, especially elderly people.

Subject Areas

vitamin D; stroke; meta-analysis

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