Preprint Article Version 1 This version is not peer-reviewed

Comparison of Oncologic Outcomes in Laparoscopic versus Open Surgery for Non-Metastatic Colorectal Cancer: Personal Experience in a Single Institution

Version 1 : Received: 30 April 2019 / Approved: 5 May 2019 / Online: 5 May 2019 (11:25:43 CEST)

A peer-reviewed article of this Preprint also exists.

Chiu, C.-C.; Lin, W.-L.; Shi, H.-Y.; Huang, C.-C.; Chen, J.-J.; Su, S.-B.; Lai, C.-C.; Chao, C.-M.; Tsao, C.-J.; Chen, S.-H.; Wang, J.-J. Comparison of Oncologic Outcomes in Laparoscopic versus Open Surgery for Non-Metastatic Colorectal Cancer: Personal Experience in a Single Institution. J. Clin. Med. 2019, 8, 875. Chiu, C.-C.; Lin, W.-L.; Shi, H.-Y.; Huang, C.-C.; Chen, J.-J.; Su, S.-B.; Lai, C.-C.; Chao, C.-M.; Tsao, C.-J.; Chen, S.-H.; Wang, J.-J. Comparison of Oncologic Outcomes in Laparoscopic versus Open Surgery for Non-Metastatic Colorectal Cancer: Personal Experience in a Single Institution. J. Clin. Med. 2019, 8, 875.

Journal reference: J. Clin. Med. 2019, 8, 875
DOI: 10.3390/jcm8060875

Abstract

The oncologic merits of laparoscopic technique for colorectal cancer surgery remain debatable. Eligible patients with non-metastatic colorectal cancer who were scheduled for an elective resection by only one surgeon in a medical institution were randomized to either laparoscopic or open treatment. During this period, total 188 patients received laparoscopic surgery and other 163 patients to open approach. The primary endpoint was cancer-free 5-year survival after operative treatment and secondary endpoint was the tumor recurrence incidence. We found there was no statistically significant difference between open and laparoscopic groups regarding average number of lymph nodes dissected, overall mortality rate, cancer recurrence rate or cancer-free 5-year survival. Nevertheless, laparoscopic approach was more effective for colorectal cancer treatment with shorter hospital stay and less blood loss despite operation time was significantly longer. Meanwhile fewer patients receiving laparoscopic approach developed postoperative urinary tract infection, wound infection, pneumonia or anastomosis leakage, which reached statistical significance. For non-metastatic colorectal cancer patients, laparoscopic surgery resulted in better short-term outcomes whether in total complications and intra-operative blood loss. Though there was no significant statistical difference in terms of cancer-free 5-year survival and tumor recurrence, we favor patients receiving laparoscopic surgery if not contraindicated.

Subject Areas

laparoscopic; open surgery; non-metastatic colorectal cancer; single surgeon experience

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