Preprint Article Version 1 This version is not peer-reviewed

Mathematical Models for Possible Roles of Oxytocin and Oxytocin Receptors in Autism

Version 1 : Received: 22 April 2019 / Approved: 23 April 2019 / Online: 23 April 2019 (11:12:19 CEST)

How to cite: Gottlieb, M. Mathematical Models for Possible Roles of Oxytocin and Oxytocin Receptors in Autism. Preprints 2019, 2019040246 (doi: 10.20944/preprints201904.0246.v2). Gottlieb, M. Mathematical Models for Possible Roles of Oxytocin and Oxytocin Receptors in Autism. Preprints 2019, 2019040246 (doi: 10.20944/preprints201904.0246.v2).

Abstract

This paper develops mathematical models examining possible roles of oxytocin and oxytocin receptors in the development of autism. This is done by demonstrating that mathematical operations on normalized data from the Stanford study (K.J. Parker, 2016), which establishes a correspondence between severity of autism in children and their oxytocin blood levels, generates a graph that is the same as the graph of mathematical operations on a normalized theoretical model for the severity of autism. This procedure establishes the validity of the theoretical model and the significance of oxytocin receptors in autism. A steady-state model follows, explaining the constant baseline concentrations of oxytocin observed in the cerebral spinal fluid and blood in terms of the neuromodulation by oxytocin of oxytocin receptors on the magnocellular neurons that produce oxytocin in nuclei in the hypothalamus.  The implications of these models for possible roles of oxytocin and oxytocin receptors in autism is considered for several unrelated conditions that may be associated with autism. These are: oxytocin receptor desensitization and down-regulation as factors during labor in offspring autism development; reductions in the oxytocin receptor numbers in the fixed oxytocin receptor expression that occurs before birth; MAST Immune System disease; and the excess number of dendritic spines from lack of pruning observed in brains of autistic people. Research into the feasibility of generating magnocellular neurons and other neurons from adult stem cells is suggested as a way of doing invitro studies of oxytocin and oxytocin receptors to assess the validity of theories presented in this paper.

Subject Areas

Oxytocin, Oxytocin Receptor, Autism, Nepsys Scale, MAST Immune System Disease, Dendritic Spines, Magnocellular Neurons, Desensitization, Labor, Down Regulation

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