Harvey, E.; Madden, D.; Polkinghorne, A.; Holmes, E.C. Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala. Viruses2019, 11, 211.
Harvey, E.; Madden, D.; Polkinghorne, A.; Holmes, E.C. Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala. Viruses 2019, 11, 211.
Harvey, E.; Madden, D.; Polkinghorne, A.; Holmes, E.C. Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala. Viruses2019, 11, 211.
Harvey, E.; Madden, D.; Polkinghorne, A.; Holmes, E.C. Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala. Viruses 2019, 11, 211.
Abstract
Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to study the immune response of koalas to ocular chlamydial infection. Using virus discovery techniques, we identified the coding-complete genome sequence of a novel picorna-like virus, denoted Burpengary virus, that was most common in south-east Queensland. Notably, abundance measurements of the virus across all 26 libraries revealed an inverse relationship in prevalence with ocular disease in Koalas, suggesting that co-infection between Burpengary virus and Chlamydia pecorum is inhibited.
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