Preprint Article Version 1 This version is not peer-reviewed

Identification of a Novel Picorna-Like Virus, Burpengary Virus, That Is Negatively Associated with Chlamydial Disease in the Koala

Version 1 : Received: 13 February 2019 / Approved: 15 February 2019 / Online: 15 February 2019 (07:33:16 CET)

A peer-reviewed article of this Preprint also exists.

Harvey, E.; Madden, D.; Polkinghorne, A.; Holmes, E.C. Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala. Viruses 2019, 11, 211. Harvey, E.; Madden, D.; Polkinghorne, A.; Holmes, E.C. Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala. Viruses 2019, 11, 211.

Journal reference: Viruses 2019, 11, 211
DOI: 10.3390/v11030211

Abstract

Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to study the immune response of koalas to ocular chlamydial infection. Using virus discovery techniques, we identified the coding-complete genome sequence of a novel picorna-like virus, denoted Burpengary virus, that was most common in south-east Queensland. Notably, abundance measurements of the virus across all 26 libraries revealed an inverse relationship in prevalence with ocular disease in Koalas, suggesting that co-infection between Burpengary virus and Chlamydia pecorum is inhibited.

Subject Areas

virus discovery; Chlamydia pecorum; Koala; picornavirus; phylogeny

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