Version 1
: Received: 7 February 2019 / Approved: 8 February 2019 / Online: 8 February 2019 (09:30:12 CET)
How to cite:
Kandilarova, S.; Stoyanov, D.; Sirakov, N.; Maes, M.; Specht, K. Reduced Grey Matter Volume in Frontal and Temporal Areas in Depression: A Voxel Based Morphometry Study. Preprints2019, 2019020078. https://doi.org/10.20944/preprints201902.0078.v1
Kandilarova, S.; Stoyanov, D.; Sirakov, N.; Maes, M.; Specht, K. Reduced Grey Matter Volume in Frontal and Temporal Areas in Depression: A Voxel Based Morphometry Study. Preprints 2019, 2019020078. https://doi.org/10.20944/preprints201902.0078.v1
Kandilarova, S.; Stoyanov, D.; Sirakov, N.; Maes, M.; Specht, K. Reduced Grey Matter Volume in Frontal and Temporal Areas in Depression: A Voxel Based Morphometry Study. Preprints2019, 2019020078. https://doi.org/10.20944/preprints201902.0078.v1
APA Style
Kandilarova, S., Stoyanov, D., Sirakov, N., Maes, M., & Specht, K. (2019). Reduced Grey Matter Volume in Frontal and Temporal Areas in Depression: A Voxel Based Morphometry Study. Preprints. https://doi.org/10.20944/preprints201902.0078.v1
Chicago/Turabian Style
Kandilarova, S., Michael Maes and Karsten Specht. 2019 "Reduced Grey Matter Volume in Frontal and Temporal Areas in Depression: A Voxel Based Morphometry Study" Preprints. https://doi.org/10.20944/preprints201902.0078.v1
Abstract
Objective: The aim of the current study was to examine whether and to what extent mood disorders, comprising major depression and bipolar disorder, are accompanied by structural changes in the brain as measured using voxel-based morphometry (VBM). Methods: We have performed a VBM study using a 3Т MRI system (GE Discovery 750w) in patients with mood disorders (n=50), namely 39 with major depression and 11 with bipolar disorder, compared to 42 age, sex and education matched healthy controls. Results: Our results show that depression was associated with significant decreases in grey matter (GM) volume restricted to regions located in medial frontal and anterior cingulate cortex on the left side and middle frontal gyrus, medial orbital gyrus, inferior frontal gyrus (triangular and orbital parts), and middle temporal gyrus (extending to the superior temporal gyrus) on the right side. When the patient group was separated into bipolar disorder and major depression the reductions remained significant only for the patients with major depressive disorder. Conclusions: Using VBM the present study was able to replicate decreases in GM volume restricted to frontal and temporal regions in patients with mood disorders mainly major depression, as compared with healthy controls.
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
