Xu, Y.; Han, J.; Dong, J.; Fan, X.; Cai, Y.; Li, J.; Wang, T.; Zhou, J.; Shang, J. Metabolomics Characterizes the Effects and Mechanisms of Quercetin in the Nonalcoholic Fatty Liver Disease Development. Preprints2019, 2019010041. https://doi.org/10.20944/preprints201901.0041.v1
APA Style
Xu, Y., Han, J., Dong, J., Fan, X., Cai, Y., Li, J., Wang, T., Zhou, J., & Shang, J. (2019). Metabolomics Characterizes the Effects and Mechanisms of Quercetin in the Nonalcoholic Fatty Liver Disease Development. Preprints. https://doi.org/10.20944/preprints201901.0041.v1
Chicago/Turabian Style
Xu, Y., Jia Zhou and Jing Shang. 2019 "Metabolomics Characterizes the Effects and Mechanisms of Quercetin in the Nonalcoholic Fatty Liver Disease Development" Preprints. https://doi.org/10.20944/preprints201901.0041.v1
Abstract
As metabolomics is widely used in the study of disease mechanisms, more and more studies have found that metabolites play an important role in the occurrence of diseases. The aim of this study is to investigate the effects and mechanisms of quercetin in high-fat-sucrose diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) development using nontargeted metabolomics. A rat model of NAFLD was established by feeding with a HFD for 30 and 50 days. Results indicated quercetin exhibited hepatoprotective activity in HFD-induced NAFLD rats in 30 days by regulating fatty acids related metabolites (adrenic acid, etc.), inflammation related metabolites (arachidonic acid, etc.), oxidative stress related metabolites (2-hydroxybutyric acid) and other differential metabolites (citric acid, etc.). However, quercetin couldn’t improve NAFLD in 50 days maybe it couldn’t reverse the inflammation condition induced by long-term high-fat diet. These data indicate that dietary quercetin may be beneficial to NAFLD at early stages. Furthermore, combining metabolomics and experimental approaches opens up avenues of effects and mechanisms of drugs for complex diseases.
Keywords
nonalcoholic fatty liver disease; high fat-sucrose diet; metabolomics; HPLC-QTOF-MS; quercetin
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
