Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Electrospun Produced 3D Matrices for Covering of Vascular Stents: Paclitaxel Release Depending on Fiber Structure and Composition of the External Environment

Konstantin A. Kuznetsov
* ,
Alena O. Stepanova
,
Ren I. Kvon
,
Timothy E.L. Douglas
,
Nikita A. Kuznetsov
ORCID logo ,
Vera S. Chernonosova
ORCID logo ,
Ivan A. Zaporozhchenko
,
Maria V. Kharkova
,
Irina V. Romanova
,
Andrey A. Karpenko
,
Pavel P. Laktionov
Version 1 : Received: 11 October 2018 / Approved: 11 October 2018 / Online: 11 October 2018 (06:09:26 CEST)

A peer-reviewed article of this Preprint also exists.

Kuznetsov, K.A.; Stepanova, A.O.; Kvon, R.I.; Douglas, T.E.L.; Kuznetsov, N.A.; Chernonosova, V.S.; Zaporozhchenko, I.A.; Kharkova, M.V.; Romanova, I.V.; Karpenko, A.A.; Laktionov, P.P. Electrospun Produced 3D Matrices for Covering of Vascular Stents: Paclitaxel Release Depending on Fiber Structure and Composition of the External Environment. Materials 2018, 11, 2176. Kuznetsov, K.A.; Stepanova, A.O.; Kvon, R.I.; Douglas, T.E.L.; Kuznetsov, N.A.; Chernonosova, V.S.; Zaporozhchenko, I.A.; Kharkova, M.V.; Romanova, I.V.; Karpenko, A.A.; Laktionov, P.P. Electrospun Produced 3D Matrices for Covering of Vascular Stents: Paclitaxel Release Depending on Fiber Structure and Composition of the External Environment. Materials 2018, 11, 2176.

Abstract

Paclitaxel is a natural, highly lipophilic anti proliferative drug widely used in medicine. We have studied the release of tritium-labeled paclitaxel (3H-PTX) from matrices destined for the coating of vascular stents and produced by the electrospinning method from the solutions of polycaprolactone (PCL) with paclitaxel (PTX) in hexafluoisoropropanol (HFIP) and/or solutions of PCL with PTX and human serum albumin (HSA) in HFIP or HIFP-dimethyl sulphoxide (DMSO) blend. The release of PTX has been shown to depend on the solvent and the composition of electrospinning solution, as well as the composition of the surrounding medium, particularly the concentration of free PTX and PTX-binding biomolecules present in human serum. It was shown that 3D matrices can completely release PTX without weight loss. Two-phase PTX release from optimized 3D matrices was obtained: ~27% of PTX was released in the first day, another 8% were released over the next 26 days. Wherein ~2.8%, ~2.3%, and ~0.25% of PTX was released on day 3, 9, and 27, respectively. Considering PTX toxicity, the rate of its diffusion through the arterial wall, and the data obtained the minimum cytostatic dose of the drug in the arterial wall will be maintained for at least three months.

Keywords

drug release; electrospinning; paclitaxel; polycaprolactone; 3D matrix

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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