Preprint Review Version 1 This version is not peer-reviewed

Role of Probiotics to Prevent and Reduce the Duration of Upper Respiratory Infections in Ambulatory Children: Systematic Review with Network-Meta Analysis

Version 1 : Received: 30 September 2018 / Approved: 1 October 2018 / Online: 1 October 2018 (10:22:49 CEST)

How to cite: Gutierrez-Castrellon, P.; Weizman, Z.; Cruchet, S.; Dinleyci, E.C.; Jimenez-Gutierrez, C.; Lopez-Velazquez, G. Role of Probiotics to Prevent and Reduce the Duration of Upper Respiratory Infections in Ambulatory Children: Systematic Review with Network-Meta Analysis. Preprints 2018, 2018100002 (doi: 10.20944/preprints201810.0002.v1). Gutierrez-Castrellon, P.; Weizman, Z.; Cruchet, S.; Dinleyci, E.C.; Jimenez-Gutierrez, C.; Lopez-Velazquez, G. Role of Probiotics to Prevent and Reduce the Duration of Upper Respiratory Infections in Ambulatory Children: Systematic Review with Network-Meta Analysis. Preprints 2018, 2018100002 (doi: 10.20944/preprints201810.0002.v1).

Abstract

Background. Upper respiratory infections (URIs) remains as significant cause of morbidity in children. Evidence on efficacy of probiotics to prevent URIs in children is increasing. This systematic review was assembled to analyze evidence about the efficacy of probiotics to reduce duration of upper respiratory infections in ambulatory children. Methods. Randomized controlled trials (RCTs) comparing probiotics vs. placebo to prevent URIs, published between 2001 and 2016 were considered. Quality evaluation was evaluated using CONSORT. Standard mean difference (SMD) or risk ratio (RR) was calculated. Network Meta-Analysis (NMA), using a random effect model was assembled. Results. 31 RCTs were evaluated and 20 studies were included with 3,635 children randomized to probiotics and 3,433 to placebo. Lactobacillus reuteri [SMD -0.56 CI95% (-0.72 to -0.41), p 0.0001] and Lactobacillus acidophillus [SMD -0.33 CI95% (-0.60 to -0.06), p 0.01] were superior to placebo to reduce duration of URIs. L. rhamnosus GG showed tendency [SMD -0.14 CI95% (-0.28 to 0.0), p 0.048]. On the network forest plot L. reuteri showed preventive equivalence when was compared to L. rhamnosus GG, L. casei and BB12. Conclusions. Lactobacillus reuteri, Lactobacillus rhamnosus GG and Bifidobacterium BB12 are evidence-based alternatives to be considered to prevent URIs in children.

Subject Areas

Probiotics, Upper Respiratory Infections, Network Meta-Analysis

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