New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity

Barbara S. Gregorí Valdes; Clara S. B. Gomes; Pedro T. Gomes; José R. Ascenso; Hermínio P. Diogo; Lídia M. Gonçalves; Rui Galhano dos Santos; Helena M. Ribeiro; João C. Bordado

doi:10.20944/preprints201809.0445.v1

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preprints.org > chemistry and materials science > organic chemistry > doi: 10.20944/preprints201809.0445.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity

Barbara S. Gregorí Valdes

^* ,

^* ,

Rui Galhano dos Santos

Helena M. Ribeiro

João C. Bordado

Version 1 : Received: 21 September 2018 / Approved: 22 September 2018 / Online: 22 September 2018 (23:23:18 CEST)

How to cite: Gregorí Valdes, B.S.; Gomes, C.S.B.; Gomes, P.T.; Ascenso, J.R.; Diogo, H.P.; Gonçalves, L.M.; Galhano dos Santos, R.; Ribeiro, H.M.; Bordado, J.C. New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity. Preprints 2018, 2018090445. https://doi.org/10.20944/preprints201809.0445.v1 Gregorí Valdes, B.S.; Gomes, C.S.B.; Gomes, P.T.; Ascenso, J.R.; Diogo, H.P.; Gonçalves, L.M.; Galhano dos Santos, R.; Ribeiro, H.M.; Bordado, J.C. New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity. Preprints 2018, 2018090445. https://doi.org/10.20944/preprints201809.0445.v1

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MDPI and ACS Style

Gregorí Valdes, B.S.; Gomes, C.S.B.; Gomes, P.T.; Ascenso, J.R.; Diogo, H.P.; Gonçalves, L.M.; Galhano dos Santos, R.; Ribeiro, H.M.; Bordado, J.C. New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity. Preprints 2018, 2018090445. https://doi.org/10.20944/preprints201809.0445.v1

APA Style

Gregorí Valdes, B.S., Gomes, C.S.B., Gomes, P.T., Ascenso, J.R., Diogo, H.P., Gonçalves, L.M., Galhano dos Santos, R., Ribeiro, H.M., & Bordado, J.C. (2018). New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity. Preprints. https://doi.org/10.20944/preprints201809.0445.v1

Chicago/Turabian Style

Gregorí Valdes, B.S., Helena M. Ribeiro and João C. Bordado. 2018 "New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity" Preprints. https://doi.org/10.20944/preprints201809.0445.v1

Abstract

The synthesis of four samples of new polyurethanes was evaluated by changing the ratio of the diol monomers used, poly(propylene glycol) (PPG) and D-isosorbide, in the presence of aliphatic isocyanates such as the isophorone diisocyanate (IPDI) and 4,4′-methylenebis(cyclohexyl isocyanate) (HMDI). The thermal properties of the four polymers obtained were determined by DSC, exhibiting Tg values in the range 55-70 ºC, and their molecular structure characterized by FTIR, 1H and 13C NMR spectroscopies. The diffusion coefficients of these polymers in solution were measured by the Pulse Gradient Spin Echo (PGSE) NMR method, enabling the calculation of the corresponding hydrodynamic radii in diluted solution (1.62–2.65 nm). The molecular weights were determined by GPC/SEC and compared with the values determined by quantitative 13C NMR analysis. Finally, the biocompatibility of the polyurethanes was assessed using the HaCaT keratinocyte cell line by the MTT reduction assay method showing values superior to 70% cell viability.

Keywords

biocompatibility; GPC/SEC; keratinocyte cells; NMR; polyurethane; renewable sources

Subject

Chemistry and Materials Science, Organic Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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