Preprint Article Version 1 This version is not peer-reviewed

New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity

Version 1 : Received: 21 September 2018 / Approved: 22 September 2018 / Online: 22 September 2018 (23:23:18 CEST)

How to cite: Gregorí Valdes, B.S.; Gomes, C.S.B.; Gomes, P.T.; Ascenso, J.R.; Diogo, H.P.; Gonçalves, L.M.; Galhano dos Santos, R.; Ribeiro, H.M.; Bordado, J.C. New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity. Preprints 2018, 2018090445 (doi: 10.20944/preprints201809.0445.v1). Gregorí Valdes, B.S.; Gomes, C.S.B.; Gomes, P.T.; Ascenso, J.R.; Diogo, H.P.; Gonçalves, L.M.; Galhano dos Santos, R.; Ribeiro, H.M.; Bordado, J.C. New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity. Preprints 2018, 2018090445 (doi: 10.20944/preprints201809.0445.v1).

Abstract

The synthesis of four samples of new polyurethanes was evaluated by changing the ratio of the diol monomers used, poly(propylene glycol) (PPG) and D-isosorbide, in the presence of aliphatic isocyanates such as the isophorone diisocyanate (IPDI) and 4,4′-methylenebis(cyclohexyl isocyanate) (HMDI). The thermal properties of the four polymers obtained were determined by DSC, exhibiting Tg values in the range 55-70 ºC, and their molecular structure characterized by FTIR, 1H and 13C NMR spectroscopies. The diffusion coefficients of these polymers in solution were measured by the Pulse Gradient Spin Echo (PGSE) NMR method, enabling the calculation of the corresponding hydrodynamic radii in diluted solution (1.62–2.65 nm). The molecular weights were determined by GPC/SEC and compared with the values determined by quantitative 13C NMR analysis. Finally, the biocompatibility of the polyurethanes was assessed using the HaCaT keratinocyte cell line by the MTT reduction assay method showing values superior to 70% cell viability.

Subject Areas

biocompatibility; GPC/SEC; keratinocyte cells; NMR; polyurethane; renewable sources

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.