Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Mediation and Moderation Analysis of the Relationship between Total Protein Concentration and the Risk of Depressive Disorders in Older Adults with Function Dependence in Home Care

Grzegorz Józef Nowicki
* ORCID logo ,
Barbara Ślusarska
ORCID logo ,
Agnieszka Bartoszek
ORCID logo ,
Katarzyna Kocka
,
Alina Deluga
,
Hanna Kachaniuk
,
Marta Łuczyk
Version 1 : Received: 5 August 2018 / Approved: 6 August 2018 / Online: 6 August 2018 (09:41:35 CEST)

A peer-reviewed article of this Preprint also exists.

Nowicki, G.J.; Ślusarska, B.; Bartoszek, A.; Kocka, K.; Deluga, A.; Kachaniuk, H.; Łuczyk, M. Moderation and Mediation Analysis of the Relationship between Total Protein Concentration and the Risk of Depressive Disorders in Older Adults with Function Dependence in Home Care. Nutrients 2018, 10, 1374. Nowicki, G.J.; Ślusarska, B.; Bartoszek, A.; Kocka, K.; Deluga, A.; Kachaniuk, H.; Łuczyk, M. Moderation and Mediation Analysis of the Relationship between Total Protein Concentration and the Risk of Depressive Disorders in Older Adults with Function Dependence in Home Care. Nutrients 2018, 10, 1374.

Abstract

Due to its devastating consequences, late life depression is an important public health problem. The aim of the study was the analysis of variables which may potentially influence risk of depression (GDS-SF). Furthermore, the aim was to study possible mediating effect of given variables on the relationship between the total protein concentration and risk of depression in older-adults with chronic diseases, and physical function impairment. The research sample included a total of 132 older adults with chronic conditions and physical function impairments, remaining under a long-term care in residential environment. Negative linear correlation was observed between patients’ physical functionality, total protein concentration, concentration of HDL cholesterol, arm circumference, and the risk of depression. Considerably stronger relationship was observed between total protein concentration, and GDS-SF, in elderly suffering from sensory dysfunction (b = −6.42, 95% CI = −11.27; −1.58). The effect of the mediation between depression risk is correlated to total protein concentration in blood serum, and the mediators are probably low function impairment and low levels of 25 (OH)D vitamin. Cohort control research is suggested to confirm the hypothesis.

Keywords

depression; total protein; elder people; physical function; long-term care

Subject

Public Health and Healthcare, Nursing

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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