Preprint Review Version 1 This version is not peer-reviewed

Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals

Version 1 : Received: 31 July 2018 / Approved: 31 July 2018 / Online: 31 July 2018 (22:34:34 CEST)

A peer-reviewed article of this Preprint also exists.

Barth, B.B.; Huang, H.-I.; Hammer, G.E.; Shen, X. Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals. Micromachines 2018, 9, 428. Barth, B.B.; Huang, H.-I.; Hammer, G.E.; Shen, X. Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals. Micromachines 2018, 9, 428.

Journal reference: Micromachines 2018, 9, 428
DOI: 10.3390/mi9090428

Abstract

Advanced electrode designs have made single-unit neural recordings commonplace among modern neuroscience research. However, single-unit resolution remains out of reach for the intrinsic neurons of the gastrointestinal system. Single-unit recordings of the enteric (gut) nervous system have been conducted in anesthetized animal models and excised tissue, but there is a large physiological gap between awake and anesthetized animals, particularly for the enteric nervous system. Here, we describe the opportunity for advancing enteric neuroscience offered by single-unit recording capabilities in awake animals. We highlight the primary challenges to microelectrodes in the gastrointestinal system including structural, physiological, and signal quality challenges.

Subject Areas

microelectrodes; in vivo electrophysiology; neural interfaces; enteric nervous system; conscious recording; electrode implantation

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.