Barth, B.B.; Huang, H.-I.; Hammer, G.E.; Shen, X. Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals. Micromachines2018, 9, 428.
Barth, B.B.; Huang, H.-I.; Hammer, G.E.; Shen, X. Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals. Micromachines 2018, 9, 428.
Advanced electrode designs have made single-unit neural recordings commonplace among modern neuroscience research. However, single-unit resolution remains out of reach for the intrinsic neurons of the gastrointestinal system. Single-unit recordings of the enteric (gut) nervous system have been conducted in anesthetized animal models and excised tissue, but there is a large physiological gap between awake and anesthetized animals, particularly for the enteric nervous system. Here, we describe the opportunity for advancing enteric neuroscience offered by single-unit recording capabilities in awake animals. We highlight the primary challenges to microelectrodes in the gastrointestinal system including structural, physiological, and signal quality challenges.
microelectrodes; in vivo electrophysiology; neural interfaces; enteric nervous system; conscious recording; electrode implantation
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