Preprint Article Version 1 This version is not peer-reviewed

Isolation of Smenopyrone, a Bis-g-Pyrone Polypropionate from the Caribbean Sponge Smenospongia Aurea.

Version 1 : Received: 27 July 2018 / Approved: 27 July 2018 / Online: 27 July 2018 (17:00:51 CEST)

A peer-reviewed article of this Preprint also exists.

Esposito, G.; Teta, R.; Della Sala, G.; Pawlik, J.R.; Mangoni, A.; Costantino, V. Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean Sponge Smenospongia aurea. Mar. Drugs 2018, 16, 285. Esposito, G.; Teta, R.; Della Sala, G.; Pawlik, J.R.; Mangoni, A.; Costantino, V. Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean Sponge Smenospongia aurea. Mar. Drugs 2018, 16, 285.

Journal reference: Mar. Drugs 2018, 16, 285
DOI: 10.3390/md16080285

Abstract

The organic extract of the Caribbean sponge Smenospongia aurea has been shown to contain an array of novel chlorinated secondary metabolites derived from a mixed PKS-NRPS biogenetic route, such as the smenamides. Here we report the presence of a biogenetically different compound, smenopyrone (1), a polypropionate containing two -pyrone rings. The structure of smenopyrone, including its relative and absolute stereochemistry, was determined by spectroscopic analysis (NMR, MS, ECD) supported by comparison with model compounds from the literature. Pyrone polypropionates are unprecedented in marine sponges, but are commonly found in marine mollusks, where their biosynthesis by symbiotic bacteria has been hypothesized and at least in one case demonstrated. As pyrones have recently been recognized as bacterial signaling molecules, we speculate that smenopyrone could mediate inter-kingdom chemical communication between S. aurea and its symbiotic bacteria.

Subject Areas

Smenospongia aurea, -pyrone, polypropionate, marine sponges, secondary metabolites, signaling molecules.

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