Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Quantum Modeling: A Bridge between the Pumping and Signaling Functions of the Na/K – ATPase

Version 1 : Received: 11 July 2018 / Approved: 12 July 2018 / Online: 12 July 2018 (05:26:21 CEST)

A peer-reviewed article of this Preprint also exists.

Wang, W.; Shapiro, J.I. Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. Int. J. Mol. Sci. 2018, 19, 2347. Wang, W.; Shapiro, J.I. Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. Int. J. Mol. Sci. 2018, 19, 2347.

Abstract

Although the signaling function of Na/K ATPase is been studied for decades, the chasm between the pumping function and the signaling function of Na/K – ATPase is still an open issue. This article explores the relationship between ion pumping and signaling with attention to the amplification of oxidants through this signaling function. Starting with some experimental observations published by our laboratories and others, we develop some predictions regarding cellular oxidant stress.

Keywords

Na/K – ATPase; Markov chain; master equation; Src; oxidant stress; reactive oxygen species; aging

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

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