Version 1
: Received: 9 July 2018 / Approved: 11 July 2018 / Online: 11 July 2018 (11:49:02 CEST)
How to cite:
Clark, T.; Jones,, J.; Hall, A.; Tabner, S.; Kmiec, R. Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in Cannabis Users. Preprints2018, 2018070197. https://doi.org/10.20944/preprints201807.0197.v1
Clark, T.; Jones,, J.; Hall, A.; Tabner, S.; Kmiec, R. Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in Cannabis Users. Preprints 2018, 2018070197. https://doi.org/10.20944/preprints201807.0197.v1
Clark, T.; Jones,, J.; Hall, A.; Tabner, S.; Kmiec, R. Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in Cannabis Users. Preprints2018, 2018070197. https://doi.org/10.20944/preprints201807.0197.v1
APA Style
Clark, T., Jones,, J., Hall, A., Tabner, S., & Kmiec, R. (2018). Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in <em>Cannabis</em> Users. Preprints. https://doi.org/10.20944/preprints201807.0197.v1
Chicago/Turabian Style
Clark, T., Sara Tabner and Rebecca Kmiec. 2018 "Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in <em>Cannabis</em> Users" Preprints. https://doi.org/10.20944/preprints201807.0197.v1
Abstract
Obesity is treatment-resistant, and is linked with a number of serious, chronic diseases. Adult obesity rates in the United States have tripled since the early 1960s. Recent reviews show that an increased ratio of omega-6 to omega-3 fatty acids contributes to obesity rates by increasing levels of the endocannabinoid signals AEA and 2-AG, overstimulating CB1R and leading to increased caloric intake, reduced metabolic rates, and weight gain. Cannabis, or THC, also stimulates CB1R and increases caloric intake during acute exposures. The present meta-analysis reveals significantly reduced body mass index and rates of obesity in Cannabis users, in conjunction with increased caloric intake. We provide for the first time a causative explanation for this paradox, in which rapid and long-lasting downregulation of CB1R following acute Cannabis consumption reduces energy intake and storage and increases metabolic rates, thus reversing the impact on body mass index of elevated dietary omega-6/omega-3 ratios.
Keywords
Cannabis, obesity, body mass index, CB1R, AEA, 2-AG, meta-analysis, theory, causation
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter:
The commenter has declared there is no conflict of interests.
https://www.liebertpub.com/doi/pdf/10.1089/can.2018.0045