Preprint Article Version 1 This version is not peer-reviewed

Fat Loss in Continuous Enteral Feeding of the Preterm Infant: How Much, What and When is it Lost?

Version 1 : Received: 6 June 2018 / Approved: 7 June 2018 / Online: 7 June 2018 (11:34:53 CEST)

A peer-reviewed article of this Preprint also exists.

Zozaya, C.; García-Serrano, A.; Fontecha, J.; Redondo-Bravo, L.; Sánchez-González, V.; Montes, M.T.; Saenz de Pipaón, M. Fat Loss in Continuous Enteral Feeding of the Preterm Infant: How Much, What and When Is It Lost? Nutrients 2018, 10, 809. Zozaya, C.; García-Serrano, A.; Fontecha, J.; Redondo-Bravo, L.; Sánchez-González, V.; Montes, M.T.; Saenz de Pipaón, M. Fat Loss in Continuous Enteral Feeding of the Preterm Infant: How Much, What and When Is It Lost? Nutrients 2018, 10, 809.

Journal reference: Nutrients 2018, 10, 809
DOI: 10.3390/nu10070809

Abstract

Human milk fat is a concentrated source of energy and provides essential and long chain polyunsaturated fatty acids. According to previous experiments, human milk fat is partially lost during continuous enteral nutrition. However, these experiments were done over relatively short infusion times, and a complete profile of the lost fatty acids was never measured. Whether this lost happens considering longer infusion times or if some fatty acids are lost more than others remain unknown. Pooled breast milk was infused through a feeding tube by a peristaltic pump over a period of 30 minutes and 4, 12 and 24 hours at 2 ml/hour. Adsorbed fat was extracted from the tubes, and the fatty acid composition was analyzed by Gas chromatography-mass spectrometry. Total fat loss (average fatty acid loss) after 24 hours was 0.6 ± 0.1%. Short-medium chain (0.7%, p=0.15), long chain (0.6%, p=0.56) saturated (0.7%, p=0.4), monounsaturated (0.5%, p=0.15), polyunsaturated fatty (0.7%, p=0.15), linoleic (0.7%, p=0.25), and docosahexaenoic acids (0.6%, p=0.56) were not selectively adsorbed to the tube. However, very long chain fatty (0.9%, p=0.04), alpha-linolenic (1.6%, p=0.02) and arachidonic acids (1%, p=0.02) were selectively adsorbed and therefore lost in a greater proportion than other fatty acids. In all cases, the magnitude of the loss was clinically low.

Subject Areas

preterm infant; enteral nutrition; lipids; omega-3 fatty acids; omega-6 fatty acids; Docosahexaenoic acid; Arachidonic acid; long-chain polyunsaturated fatty acids.

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