Preprint Case Report Version 2 This version is not peer-reviewed

Growth Hormone (GH) Administration Increases the Metabolic Activity of the Left Hippocampus in an Elder Patient with Cognitive Disorders

Version 1 : Received: 9 May 2018 / Approved: 9 May 2018 / Online: 9 May 2018 (14:34:03 CEST)
Version 2 : Received: 4 June 2018 / Approved: 5 June 2018 / Online: 5 June 2018 (15:18:11 CEST)

A peer-reviewed article of this Preprint also exists.

Devesa, J.; Núñez, I.; Agra, C.; Bejarano, A.; Devesa, P. Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype. Int. J. Mol. Sci. 2018, 19, 2294. Devesa, J.; Núñez, I.; Agra, C.; Bejarano, A.; Devesa, P. Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype. Int. J. Mol. Sci. 2018, 19, 2294.

Journal reference: Int. J. Mol. Sci. 2018, 19, 2294
DOI: 10.3390/ijms19082294

Abstract

1) Background: We analyzed, by PET-SCAN, how growth hormone (GH) could act on the brain of an older woman, not GH-deficient, which was beginning to show some cognitive deficiencies and presented an ApoE genotype 4/3; 2) Methods: After performing a first psychometric study (TAVEC verbal learning test), the metabolic activity of brain structures related to knowledge, memory, and behavior was analyzed using 18-F Fluorodeoxyglucose PET-SCAN. The patient was then treated with GH (0.4 mg/day) for three weeks and on the last day under this treatment, a new PET-SCAN was performed. One month after beginning treatment with GH, a new TAVEC test was performed; 3) Results: GH administration normalized the cognitive deficits observed in the first psychometric test and increased significantly (P < 0.025) the metabolic activity in practically all brain cortical areas, specifically in the left hippocampus and left amygdala, although not in the left parahippocampus; and 4) Conclusions: This is the first study in which the positive effects of GH on cerebral metabolism have been visualized in a human patient. Our data confirm the positive effects of this hormone on cognition, memory and behavior in patients affected by mild cognitive impairments.

Subject Areas

Growth Hormone; cognition; recent memory; PET-SCAN; hippocampus; amygdala; parahippocampus; ApoE genotype.

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