Preprint Article Version 1 This version is not peer-reviewed

Indirubin inhibits cell proliferation, migration, invasion and
angiogenesis in tumor-derived endothelial cells

Version 1 : Received: 20 June 2017 / Approved: 20 June 2017 / Online: 20 June 2017 (11:30:51 CEST)

How to cite: zhuohong, L.; chaofu, Z.; baiping, A.; yu, C.; xinyue, H.; Lin, Q.; lan, L.; Li, S. Indirubin inhibits cell proliferation, migration, invasion and
angiogenesis in tumor-derived endothelial cells. Preprints 2017, 2017060097 (doi: 10.20944/preprints201706.0097.v1). zhuohong, L.; chaofu, Z.; baiping, A.; yu, C.; xinyue, H.; Lin, Q.; lan, L.; Li, S. Indirubin inhibits cell proliferation, migration, invasion andangiogenesis in tumor-derived endothelial cells. Preprints 2017, 2017060097 (doi: 10.20944/preprints201706.0097.v1).

Abstract

Hepatocellular Carcinoma is one of the most predominant malignancies with high fatality rate and is rising at an alarming rate because it is quite resistant to radioand chemotherapy. The proliferation, migration and activation of endothelial cells are involved in tumor occurrence and development. Indirubin is the major active anti-tumor ingredient of a traditional Chinese herbal medicine. In this research, Td-ECs were derived from human umbilical vein endothelial cells (HUVECs) by treating HUVECs with the conditioned medium of human liver cancer cell line HepG2. The effects of indirubin on cell proliferation, migration, invasion and angiogenesis of Td-ECs were assessed. Indirubin significantly inhibited Td-EC cell proliferation in a dose- and time-dependent manner. Indirubin also inhibited Td-EC
migration and angiogenesis. However, indirubin’s effects on HUVECs were weaker than on Td-ECs.

Subject Areas

Indirubin; Td-EC; proliferation; migration; invasion; angiogenesis

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