Jaśkiewicz, M.; Neubauer, D.; Kamysz, W. Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media. Antibiotics2017, 6, 15.
Jaśkiewicz, M.; Neubauer, D.; Kamysz, W. Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media. Antibiotics 2017, 6, 15.
Jaśkiewicz, M.; Neubauer, D.; Kamysz, W. Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media. Antibiotics2017, 6, 15.
Jaśkiewicz, M.; Neubauer, D.; Kamysz, W. Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media. Antibiotics 2017, 6, 15.
Abstract
Staphylococcus aureus bacteria are one of the leading microorganisms responsible for nosocomial infections as well as being the primary causative pathogen of skin and wound infections. Currently, the therapy of staphylococcal diseases faces many difficulties, due to a variety of mechanisms of resistance and virulence factors. Moreover, a number of infections caused by S. aureus is connected with biofilm formation that impairs effectiveness of the therapy. Short cationic lipopeptides that are designed on the basis of the structure of antimicrobial peptides structure are likely to provide a promising alternative to conventional antibiotics. Despite the fact that many research groups have proved a high antistaphylococcal potential of lipopeptides, the lack of unified protocols in determination of antimicrobial activity may be the reason of inconsistency of the results. The aim of this study was to learn how the use of various bacteriological media as well as solvents may affect activity of lipopeptides and their cyclic analogs.
Keywords
antimicrobial peptides; lipopeptides; cyclic lipopeptides Staphylococcus aureus; biofilm; culture media
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
