Resorbable Bilayer Membrane Made of L-Lactide-ε-Caprolactone in Guided Bone Regeneration: An In Vivo Experimental Study

Taito Watanabe; Akira Hasuike; Shin Wakuda; Keisuke Kogure; Seiko Min; Norihisa Watanabe; Ryo Sakai; Yoshinori Arai; Shuichi Sato

doi:10.20944/preprints202306.0997.v1

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preprints.org > medicine and pharmacology > clinical medicine > doi: 10.20944/preprints202306.0997.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Resorbable Bilayer Membrane Made of L-Lactide-ε-Caprolactone in Guided Bone Regeneration: An In Vivo Experimental Study

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Version 1 : Received: 13 June 2023 / Approved: 14 June 2023 / Online: 14 June 2023 (07:10:22 CEST)

A peer-reviewed article of this Preprint also exists.

Watanabe, T.; Hasuike, A.; Wakuda, S.; Kogure, K.; Min, S.; Watanabe, N.; Sakai, R.; Chaurasia, A.; Arai, Y.; Sato, S. Resorbable Bilayer Membrane Made of L-Lactide-ε-Caprolactone in Guided Bone Regeneration: An in Vivo Experimental Study. International Journal of Implant Dentistry 2024, 10, doi:10.1186/s40729-024-00520-7. Watanabe, T.; Hasuike, A.; Wakuda, S.; Kogure, K.; Min, S.; Watanabe, N.; Sakai, R.; Chaurasia, A.; Arai, Y.; Sato, S. Resorbable Bilayer Membrane Made of L-Lactide-ε-Caprolactone in Guided Bone Regeneration: An in Vivo Experimental Study. International Journal of Implant Dentistry 2024, 10, doi:10.1186/s40729-024-00520-7.

Abstract

Insufficient oral ridge tissue presents a challenge in the treatment of dental implants. One method to enhance alveolar crest dimensions is guided bone regeneration (GBR); however, existing membranes have certain limitations. To address this issue, we aimed to compare the effectiveness of a resorbable bilayer membrane composed of poly(l-lactic acid) and poly(-caprolactone) （PLACL）with that of a collagen membrane（COL） in a rat GBR model. The rat calvaria was used as an experimental model by placing a plastic cylinder. Forty male Fisher rats underwent surgery, and micro-computed tomography and histomorphometric analyses were performed to assess bone regeneration. The results showed that bone regeneration was similar across all the groups. However, after 24 weeks, the PLACL membrane demonstrated significant resilience, occasional partial degradation, and intermittent air bubble formation. This extended preservation of the barrier effect has great potential to facilitate optimal bone regeneration. In conclusion, this study shows that the PLACL membrane is a promising alternative to GBR. By providing a durable barrier and supporting bone regeneration over an extended period, this resorbable bilayer membrane may address the limitations of the current membranes. Further studies and clinical trials are warranted to validate the efficacy and safety of this drug in humans.

Keywords

Guided Bone Regeneration; dental implant; PLACL; resorbable bilayer membrane

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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