PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
The Surgical, Histopathological Characteristics, and Survival Outcome of Ovarian Clear Cell Carcinoma: A Retrospective Case Series Sharing the Experience of a Tertiary Cancer Centre over 10 Years
Version 1
: Received: 7 April 2023 / Approved: 10 April 2023 / Online: 10 April 2023 (05:14:42 CEST)
How to cite:
EL Tawab, S.; Nistor, S.; Roux, R.; Manek, S.; Geitskell, K.; Ahmed, A.; Kehoe, S.; Soleymani majd, H. The Surgical, Histopathological Characteristics, and Survival Outcome of Ovarian Clear Cell Carcinoma: A Retrospective Case Series Sharing the Experience of a Tertiary Cancer Centre over 10 Years. Preprints2023, 2023040151. https://doi.org/10.20944/preprints202304.0151.v1
EL Tawab, S.; Nistor, S.; Roux, R.; Manek, S.; Geitskell, K.; Ahmed, A.; Kehoe, S.; Soleymani majd, H. The Surgical, Histopathological Characteristics, and Survival Outcome of Ovarian Clear Cell Carcinoma: A Retrospective Case Series Sharing the Experience of a Tertiary Cancer Centre over 10 Years. Preprints 2023, 2023040151. https://doi.org/10.20944/preprints202304.0151.v1
EL Tawab, S.; Nistor, S.; Roux, R.; Manek, S.; Geitskell, K.; Ahmed, A.; Kehoe, S.; Soleymani majd, H. The Surgical, Histopathological Characteristics, and Survival Outcome of Ovarian Clear Cell Carcinoma: A Retrospective Case Series Sharing the Experience of a Tertiary Cancer Centre over 10 Years. Preprints2023, 2023040151. https://doi.org/10.20944/preprints202304.0151.v1
APA Style
EL Tawab, S., Nistor, S., Roux, R., Manek, S., Geitskell, K., Ahmed, A., Kehoe, S., & Soleymani majd, H. (2023). The Surgical, Histopathological Characteristics, and Survival Outcome of Ovarian Clear Cell Carcinoma: A Retrospective Case Series Sharing the Experience of a Tertiary Cancer Centre over 10 Years. Preprints. https://doi.org/10.20944/preprints202304.0151.v1
Chicago/Turabian Style
EL Tawab, S., Sean Kehoe and Hooman Soleymani majd. 2023 "The Surgical, Histopathological Characteristics, and Survival Outcome of Ovarian Clear Cell Carcinoma: A Retrospective Case Series Sharing the Experience of a Tertiary Cancer Centre over 10 Years" Preprints. https://doi.org/10.20944/preprints202304.0151.v1
Abstract
A retrospective study including 49 women with ovarian clear cell carcinoma between January 2009 and December 2021 at Oxford cancer centre was done. The mean age was 63 years, with 78% post-menopausal. All women underwent cytoreductive surgery with no residual disease (R0) in 39 women. The follow-up time ranged between 12-144 months, with mean of 105.5 months. The 3-year OS was 73.4%, and 3-year PFS was 81.3%, with a mean of 101.7months (95%CI, 84.63-118.93). As expected, women with stage 1 disease had the best outcome. In comparing OS in respect to absence or presence of residual disease, the 3-year OS was 88.6% (95% CI 108.6-141.8), compared to 12.5% (95% CI 4.48-32.11) respectively (P<0.001). In multivariant analysis the variables included were CA 125 (< or >200 IU/ml), Hb (< or >115 g/L), albumin (< or >40 g/L), associated endometriosis, ascites, residual disease, and FIGO staging. FIGO stage was the only independent prognostic indicator of OS with (p<0.05). Surgery to achieve no residual tumour is necessary to improve the prognosis in advanced OCCC. At present, the true challenge is to predict which patients with early-stage disease are at higher risk of recurrence and would most benefit from adjuvant treatments.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
