Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Role of Glial Cells in Depression and Drug Addiction

Yousef Tizabi
* ORCID logo ,
Bruk Getachew
,
Sheketha R. Hauser
,
Vassiliy Tsytsarev
ORCID logo ,
Alex C. Manhães
,
Victor Diogenes Amaral da Silva
ORCID logo
Version 1 : Received: 2 May 2024 / Approved: 3 May 2024 / Online: 3 May 2024 (07:46:47 CEST)

How to cite: Tizabi, Y.; Getachew, B.; Hauser, S. R.; Tsytsarev, V.; Manhães, A. C.; da Silva, V. D. A. Role of Glial Cells in Depression and Drug Addiction. Preprints 2024, 2024050173. https://doi.org/10.20944/preprints202405.0173.v1 Tizabi, Y.; Getachew, B.; Hauser, S. R.; Tsytsarev, V.; Manhães, A. C.; da Silva, V. D. A. Role of Glial Cells in Depression and Drug Addiction. Preprints 2024, 2024050173. https://doi.org/10.20944/preprints202405.0173.v1

Abstract

Major depressive disorder (MDD) and substance use disorder (SUD) are of immense medical and social concerns. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, only relatively recently the role of glia in these disorders have attracted attention. Detail understanding of the glial function in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, specific contribution of the neurotrophic factors, neuroinflammation and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes and synantocytes) on phenotypic manifestation of MDD or SUD are emphasized. In addition, potential use of this knowledge in developing novel therapeutics is touched upon.

Keywords

astrocytes; glial cells; gut microbiota; major depressive disorder; microglia; neuroinflammation; neurotrophic factors; oligodendrocytes; substance use disorder; synantocytes

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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