Abenavoli, L.; Gambardella, M.L.; Scarlata, G.G.M.; Lenci, I.; Baiocchi, L.; Luzza, F. The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation. Medicina2024, 60, 563.
Abenavoli, L.; Gambardella, M.L.; Scarlata, G.G.M.; Lenci, I.; Baiocchi, L.; Luzza, F. The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation. Medicina 2024, 60, 563.
Abenavoli, L.; Gambardella, M.L.; Scarlata, G.G.M.; Lenci, I.; Baiocchi, L.; Luzza, F. The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation. Medicina2024, 60, 563.
Abenavoli, L.; Gambardella, M.L.; Scarlata, G.G.M.; Lenci, I.; Baiocchi, L.; Luzza, F. The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation. Medicina 2024, 60, 563.
Abstract
The gastrointestinal tract is inhabited by the gut microbiota. The main phyla are Firmicutes and Bacteroidetes. In non-alcoholic fatty liver disease, now renamed metabolic dysfunction-associated fatty liver disease (MAFLD), an increase in Firmicutes and Bacteroidetes abundance promotes its pathogenesis and evolution into non-alcoholic steatohepatitis, liver cirrhosis and hepatocellular carcinoma. For this reason, an early treatment is necessary to disfavor its progression. The aim of the present narrative review is to evaluate the different therapeutic approaches to MAFLD. The most important treatment for MAFLD is lifestyle changes. In this regard, the Mediterranean diet could be considered the gold standard in the prevention and treatment of MAFLD. In contrast, a Western diet should be discouraged. Probiotics and fecal microbiota transplantation seem to be valid, safe, and effective alternatives for MAFLD treatment. However, more studies with a longer follow up and with a larger cohort of patients are needed to underline the more effective ap-proaches to contrasting MAFLD.
Keywords
Steatosis; Probiotics; Gut-liver axis; Leaky gut
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
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