Version 1
: Received: 2 March 2024 / Approved: 4 March 2024 / Online: 4 March 2024 (11:13:50 CET)
How to cite:
Bretto, E.; Caviglia, G.P.; Saracco, G.M.; Bugianesi, E.; Ribaldone, D.G. Cross Talk between Gut Microbiota and Immune System: From Pathophysiology to Potential Therapeutic Interventions in Inflammatory Bowel Disease. Preprints2024, 2024030139. https://doi.org/10.20944/preprints202403.0139.v1
Bretto, E.; Caviglia, G.P.; Saracco, G.M.; Bugianesi, E.; Ribaldone, D.G. Cross Talk between Gut Microbiota and Immune System: From Pathophysiology to Potential Therapeutic Interventions in Inflammatory Bowel Disease. Preprints 2024, 2024030139. https://doi.org/10.20944/preprints202403.0139.v1
Bretto, E.; Caviglia, G.P.; Saracco, G.M.; Bugianesi, E.; Ribaldone, D.G. Cross Talk between Gut Microbiota and Immune System: From Pathophysiology to Potential Therapeutic Interventions in Inflammatory Bowel Disease. Preprints2024, 2024030139. https://doi.org/10.20944/preprints202403.0139.v1
APA Style
Bretto, E., Caviglia, G.P., Saracco, G.M., Bugianesi, E., & Ribaldone, D.G. (2024). Cross Talk between Gut Microbiota and Immune System: From Pathophysiology to Potential Therapeutic Interventions in Inflammatory Bowel Disease. Preprints. https://doi.org/10.20944/preprints202403.0139.v1
Chicago/Turabian Style
Bretto, E., Elisabetta Bugianesi and Davide Giuseppe Ribaldone. 2024 "Cross Talk between Gut Microbiota and Immune System: From Pathophysiology to Potential Therapeutic Interventions in Inflammatory Bowel Disease" Preprints. https://doi.org/10.20944/preprints202403.0139.v1
Abstract
Inflammatory bowel disease (IBD), a heterogeneous group of recurring inflammatory condi-tions of the digestive system that encompass both ulcerative colitis (UC) and Crohn’s disease (CD), pose a significant public health challenge, currently lacking a definitive cure. The specif-ic etiopathogenesis of IBD is not yet fully understood, but a multifactorial interplay of genetic and environmental factors is suspected. A growing body of evidence supports the involve-ment of intestinal dysbiosis in the development of IBD, including the effects of dysbiosis on the integrity of the intestinal epithelial barrier, modulation of the host immune system, alter-ations in the enteric nervous system, and the perpetuation of chronic inflammation. A com-prehensive understanding of these mechanisms is important to define preventive measures, to develop new effective and lasting treatments and to improve disease outcome. This review examines the complex tri-directional relationship between gut microbiota, mucosal immune system, and intestinal epithelium in IBD. In addition, nonpharmacological and behavioral strategies aimed at restoring a proper microbial-immune relationship will be suggested.
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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