Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Evening-Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors. A Narrative Review.

Luca Magnani
ORCID logo ,
Andrea Aguglia
ORCID logo ,
Jacques Alexander
,
Alessandra Maiorano
,
Hélène Richard-Lepouriel
ORCID logo ,
Sidonia Paula Iancau
ORCID logo ,
Andrea Amerio
ORCID logo ,
Alberto Parise
,
Gianluca Serafini
ORCID logo ,
Mario Amore
,
Philippe Huguelet
,
Khoa D. Nguyen
,
Costanza Alessandra
* ORCID logo
Version 1 : Received: 11 December 2023 / Approved: 11 December 2023 / Online: 11 December 2023 (18:00:47 CET)

A peer-reviewed article of this Preprint also exists.

Magnani, L.; Aguglia, A.; Alexander, J.; Maiorano, A.; Richard-Lepouriel, H.; Iancau, S.P.; Amerio, A.; Parise, A.; Serafini, G.; Amore, M.; Nguyen, K.D.; Costanza, A. Evening Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors—A Narrative Review. Brain Sci. 2024, 14, 30. Magnani, L.; Aguglia, A.; Alexander, J.; Maiorano, A.; Richard-Lepouriel, H.; Iancau, S.P.; Amerio, A.; Parise, A.; Serafini, G.; Amore, M.; Nguyen, K.D.; Costanza, A. Evening Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors—A Narrative Review. Brain Sci. 2024, 14, 30.

Abstract

Abstract: Background: chronotype is generally defined as the variability of the phase angle of en-trainment, while the latter reflects the relationship between the timing of a certain rhythm (e.g., sleep-wake cycle) and the timing of an external temporal cue. Individuals can be placed on a spectrum from "morning types" (M types), to "evening types" (E types). E-chronotype has been proposed as a transdiagnostic risk factor for psychiatric conditions and associated with psycho-pathological dimensions. Eveningness seems correlated with both suicidal ideation (SI) and suicidal behavioral (SB), through several possible mediating factors. Immunological alterations also have been linked to later chronotypes and SI/SB. Objective: This narrative review aims to summarize the evidence supporting the possible association between chronotypes and suicide, with the eventual mediating role of neuroinflammation and several psychopathological dimensions. Material and methods: A search of literature (2003-2023) was conducted, using various databases: PUBMED, EMBASE, Scopus, UpToDate, PsycINFO, Cochrane Library. English-language articles were col-lected and screened for eligibility. Results: Despite the apparent absence of a direct correlation between E-chronotype and suicidality, E-chronotype promotes a chain of effects that could be in-volved in an increased risk of SB, in which with neuroinflammation possibly play an intriguing role and some psychopathological dimensions may stand out.

Keywords

chronotype; eveningness; E-chronotype; social jet leg; mood dysregulation; seasonality; depression; inflammation; neuroinflammation; suicidal ideation; suicidal behavior

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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