Chechushkov, A.; Desyukevich, P.; Yakovlev, T.; Al Allaf, L.; Shrainer, E.; Morozov, V.; Tikunova, N. Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients. Int. J. Mol. Sci.2024, 25, 1886.
Chechushkov, A.; Desyukevich, P.; Yakovlev, T.; Al Allaf, L.; Shrainer, E.; Morozov, V.; Tikunova, N. Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients. Int. J. Mol. Sci. 2024, 25, 1886.
Chechushkov, A.; Desyukevich, P.; Yakovlev, T.; Al Allaf, L.; Shrainer, E.; Morozov, V.; Tikunova, N. Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients. Int. J. Mol. Sci.2024, 25, 1886.
Chechushkov, A.; Desyukevich, P.; Yakovlev, T.; Al Allaf, L.; Shrainer, E.; Morozov, V.; Tikunova, N. Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients. Int. J. Mol. Sci. 2024, 25, 1886.
Abstract
Ulcerative colitis is a chronic immune-mediated disease of unclear etiology, affecting people of different ages and significantly reducing the quality of life. Modern methods of therapy are mainly represented by anti-inflammatory drugs and are not aimed at a specific pathogenetic factor. In this study, we investigated the effect of transplantation of sterile stool filtrate from healthy donors on the induction of anti-inflammatory immune mechanisms. It was shown that performing such a procedure in patients with ulcerative colitis caused the appearance of T helper cells in the blood, which reacted to the content of sterile stool filtrates in an antigen-specific manner and produced IL10. At the same time, cells of the same patients before therapy in response to the addition of sterile stool filtrates were less reactive and predominantly produced IL4, indicating its pro-inflammatory skewing. The obtained data demonstrated the effect of an anti-inflammatory shift in the T-helper response after transplantation of sterile stool filtrate, which increased and persisted for at least three months after the procedure.
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