Version 1
: Received: 9 October 2023 / Approved: 9 October 2023 / Online: 10 October 2023 (06:16:56 CEST)
How to cite:
Mistiaen, W. Review Article: Transfusion of Blood Products in Cardiac Surgery for Endocarditis: Predictors and Consequences. Preprints2023, 2023100549. https://doi.org/10.20944/preprints202310.0549.v1
Mistiaen, W. Review Article: Transfusion of Blood Products in Cardiac Surgery for Endocarditis: Predictors and Consequences. Preprints 2023, 2023100549. https://doi.org/10.20944/preprints202310.0549.v1
Mistiaen, W. Review Article: Transfusion of Blood Products in Cardiac Surgery for Endocarditis: Predictors and Consequences. Preprints2023, 2023100549. https://doi.org/10.20944/preprints202310.0549.v1
APA Style
Mistiaen, W. (2023). Review Article: Transfusion of Blood Products in Cardiac Surgery for Endocarditis: Predictors and Consequences. Preprints. https://doi.org/10.20944/preprints202310.0549.v1
Chicago/Turabian Style
Mistiaen, W. 2023 "Review Article: Transfusion of Blood Products in Cardiac Surgery for Endocarditis: Predictors and Consequences" Preprints. https://doi.org/10.20944/preprints202310.0549.v1
Abstract
Infective endocarditis (IE) is a serious condition with a high mortality rate, even after surgery. Need for transfusion might be increased in surgery for IE. This review aims to identify the predictors for the need of transfusion in IE patients and the effect of transfusion on outcome. Only 17 manuscripts could be identified partially addressing this issue. Minimal access surgery and valve repair instead of replacement seems favorable in this respect. However, IE has opposing effects on the coagulation system with increase in bleeding and thromboembolic events. There are indications that in IE patients, transfusion need is higher but this might be compounded by the complexity of surgery and a prolonged cardiopulmonary bypass (CPB) time. Since organ dysfunction is associated with IE, this comorbidity could cloud the effect of the need for transfusion on outcome. To avoid potential adverse effect of transfusion, alternative methods have been proposed such as the use of cytokine absorbers during CPB run, intraoperative cell salvage and acute normovolemic hemodilution. These methods need further study in this subgroup of patients. In the meantime, allogeneic transfusion should be kept at a minimum, using only recently stored blood, to minimize harmful effects.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
