Version 1
: Received: 30 June 2023 / Approved: 30 June 2023 / Online: 3 July 2023 (03:12:41 CEST)
How to cite:
De Simoni, E.; Candelora, M.; Belleggia, S.; Molinelli, E.; Rizzetto, G.; Ferretti, G.; Bacchetti, T.; Capodaglio, I.; Offidani, A.; Simonetti, O. Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis. Preprints2023, 2023062234. https://doi.org/10.20944/preprints202306.2234.v1
De Simoni, E.; Candelora, M.; Belleggia, S.; Molinelli, E.; Rizzetto, G.; Ferretti, G.; Bacchetti, T.; Capodaglio, I.; Offidani, A.; Simonetti, O. Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis. Preprints 2023, 2023062234. https://doi.org/10.20944/preprints202306.2234.v1
De Simoni, E.; Candelora, M.; Belleggia, S.; Molinelli, E.; Rizzetto, G.; Ferretti, G.; Bacchetti, T.; Capodaglio, I.; Offidani, A.; Simonetti, O. Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis. Preprints2023, 2023062234. https://doi.org/10.20944/preprints202306.2234.v1
APA Style
De Simoni, E., Candelora, M., Belleggia, S., Molinelli, E., Rizzetto, G., Ferretti, G., Bacchetti, T., Capodaglio, I., Offidani, A., & Simonetti, O. (2023). Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis. Preprints. https://doi.org/10.20944/preprints202306.2234.v1
Chicago/Turabian Style
De Simoni, E., Annamaria Offidani and Oriana Simonetti. 2023 "Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis" Preprints. https://doi.org/10.20944/preprints202306.2234.v1
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by itching, impaired epidermal barrier function and unbalanced inflammatory response. The pathophysiology involves immune dysregulation, with a predominance of T-helper 2 cells.
AD is triggered by many known and unknown factors, including oxidative stress. Reactive oxygen species (ROS) contribute to AD pathogenesis by causing cellular damage and inflammation. Moreover, increased oxidative stress in AD leads to hyperactivation of the MAP kinase pathway, extracellular signal-regulated kinase (ERK) and p38, with DNA damage and subsequent skin barrier dysfunction.
This narrative review provides a comprehensive overview of the role of natural antioxidant compounds, highlighting their potential therapeutic value in AD management. They include vitamin D, vitamin E, pyridoxine (vitamin B6), Vitamin C, carotenoids and melatonin, in AD. Despite some studies have shown an association between vitamin D, vitamin E, vitamin C and carotenoids levels and AD course, conflicting results exist. Pyridoxine supplementation has shown mixed results, and melatonin has demonstrated antioxidant and anti-inflammatory properties in AD; in fact, melatonin treatment resulted in a decrease in symptoms in patients with AD, although no significant correlation with changes in sleep latency was reported. In addition, iron and zinc (Zn) supplementation can also improve AD symptoms.
Further research is needed to elucidate the optimal use of these natural antioxidants in AD treatment
Keywords
atopic dermatitis; antioxidant agents; oxidative stress; reactive oxygen species
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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