Wu, L.-Y.; Song, Y.-J.; Zhang, C.-L.; Liu, J. KV Channel-Interacting Proteins in the Neurological and Cardiovascular Systems: An Updated Review. Cells2023, 12, 1894.
Wu, L.-Y.; Song, Y.-J.; Zhang, C.-L.; Liu, J. KV Channel-Interacting Proteins in the Neurological and Cardiovascular Systems: An Updated Review. Cells 2023, 12, 1894.
Wu, L.-Y.; Song, Y.-J.; Zhang, C.-L.; Liu, J. KV Channel-Interacting Proteins in the Neurological and Cardiovascular Systems: An Updated Review. Cells2023, 12, 1894.
Wu, L.-Y.; Song, Y.-J.; Zhang, C.-L.; Liu, J. KV Channel-Interacting Proteins in the Neurological and Cardiovascular Systems: An Updated Review. Cells 2023, 12, 1894.
Abstract
KV channel-interacting proteins (KChIPs) belong to a family of Ca2+-binding EF-hand proteins that are able to bind to the N-terminus of the KV4 channel α-subunits. As the auxiliary subunit, KChIPs are critically involved in regulating the amplitude and gating properties of KV4 channels by modulating their cell surface trafficking, voltage-dependent activation, inactivation kinetics, and recovery rate from inactivation. IKs, ICa,L, and INa can also be regulated by KChIPs. KChIPs are predominantly expressed in the brain and heart, where they contribute to the maintenance of the excitability of neurons and cardiomyocytes by modulating the KV4 currents. Interestingly, all KChIPs can act as transcription factors to control the expression of genes involved in pain, memory, and circadian regulation. Altered expression of KChIPs has been implicated in the pathogenesis of many diseases, such as arrhythmia, heart failure, Alzheimer's disease, etc. In this review, we summarize the research progress of KChIPs in their structural properties, physiological functions, and pathological roles in disease progression, and provide an overview of the therapeutic potential of KChIPs as pharmacological targets for associated disorders.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
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