Bous, M.; Schmitt, C.; Hans, M.C.; Weber, R.; Nourkami-Tutdibi, N.; Tenbruck, S.; Haj Hamoud, B.; Wagenpfeil, G.; Kaiser, E.; Solomayer, E.-F.; Zemlin, M.; Goedicke-Fritz, S. Sex Differences in the Frequencies of B and T Cell Subpopulations of Human Cord Blood. Int. J. Mol. Sci.2023, 24, 11511.
Bous, M.; Schmitt, C.; Hans, M.C.; Weber, R.; Nourkami-Tutdibi, N.; Tenbruck, S.; Haj Hamoud, B.; Wagenpfeil, G.; Kaiser, E.; Solomayer, E.-F.; Zemlin, M.; Goedicke-Fritz, S. Sex Differences in the Frequencies of B and T Cell Subpopulations of Human Cord Blood. Int. J. Mol. Sci. 2023, 24, 11511.
Bous, M.; Schmitt, C.; Hans, M.C.; Weber, R.; Nourkami-Tutdibi, N.; Tenbruck, S.; Haj Hamoud, B.; Wagenpfeil, G.; Kaiser, E.; Solomayer, E.-F.; Zemlin, M.; Goedicke-Fritz, S. Sex Differences in the Frequencies of B and T Cell Subpopulations of Human Cord Blood. Int. J. Mol. Sci.2023, 24, 11511.
Bous, M.; Schmitt, C.; Hans, M.C.; Weber, R.; Nourkami-Tutdibi, N.; Tenbruck, S.; Haj Hamoud, B.; Wagenpfeil, G.; Kaiser, E.; Solomayer, E.-F.; Zemlin, M.; Goedicke-Fritz, S. Sex Differences in the Frequencies of B and T Cell Subpopulations of Human Cord Blood. Int. J. Mol. Sci. 2023, 24, 11511.
Abstract
Background: Cord blood represents a link between intrauterine and early extrauterine development. Cord blood cells map an important time frame in human immune imprinting processes. It is unknown whether sex of the newborn affects the lymphocyte subpopulations in cord blood. Methods: 9 B and 21 T cell subpopulations were characterized by flow cytometry in human cord blood from 16 male and 21 female newborns, respectively. Results: Except for marginal zone B cells and transitional B cells, B cell count in all subsets was higher in cord blood of male newborns than in female newborns. Frequency of naive thymus negative Th cells was significantly higher in male cord blood whereas the remaining T cell subpopulations showed a higher count in cord blood of female newborns. Conclusion: Our study is the first revealing sex differences in B and T cell subpopulations of human cord blood. These results indicate that sex might have a higher impact for the developing immune system urging the need to expand research in this area.
Keywords
B cells; T cells; B1 cells; human; white blood cells; cord blood; development; ontogeny; sex differences; gender medicine
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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