Version 1
: Received: 6 June 2023 / Approved: 7 June 2023 / Online: 7 June 2023 (12:11:19 CEST)
How to cite:
Ozbay, S.; Ayan, M.; Eroz, R.; Saritas, A. Detection of Brain Tissue Damage in CO Poisoning with a New Method. Preprints2023, 2023060551. https://doi.org/10.20944/preprints202306.0551.v1
Ozbay, S.; Ayan, M.; Eroz, R.; Saritas, A. Detection of Brain Tissue Damage in CO Poisoning with a New Method. Preprints 2023, 2023060551. https://doi.org/10.20944/preprints202306.0551.v1
Ozbay, S.; Ayan, M.; Eroz, R.; Saritas, A. Detection of Brain Tissue Damage in CO Poisoning with a New Method. Preprints2023, 2023060551. https://doi.org/10.20944/preprints202306.0551.v1
APA Style
Ozbay, S., Ayan, M., Eroz, R., & Saritas, A. (2023). Detection of Brain Tissue Damage in CO Poisoning with a New Method. Preprints. https://doi.org/10.20944/preprints202306.0551.v1
Chicago/Turabian Style
Ozbay, S., Recep Eroz and Ayhan Saritas. 2023 "Detection of Brain Tissue Damage in CO Poisoning with a New Method" Preprints. https://doi.org/10.20944/preprints202306.0551.v1
Abstract
We aimed to evaluate the effect of hypoxia caused by different levels of chronic carbon monoxide (CO) exposure via total AgNOR area/total nuclear area (TAA/TNA) ratio and mean AgNOR number on rat brain tissue. Eighteen Albino Wistar adult male rats were randomly divided into three groups (control as group A, 1000ppm and 3000ppm concentration of CO gas exposed as group B and C, respectively). CO gas was chronically given as 30 min a day during seven days. Statistically significant differences were found among the groups for both mean AgNOR number (χ2=12.051, p=0.002) and TAA/TNA (χ2=12.316, p=0.002), respectively. When the two groups are compared in terms of TAA/TNA ratio, statistically significant differences were detected between control and 1000ppm (Z=-2.882, p=0.004), between control and 3000 ppm (Z=-2.882, p=0.004) for TAA/TNA ratio. Statistically significant differences were found between control and 1000 ppm (Z=-2.882, p=0.004), between control and 3000 ppm (Z=-2.887, p=0.004) for mean AgNOR number. It is important to determine new markers with high sensitivity and easy to apply in order to determine the effect of toxication in different organs and tissues (especially brain tissues) that are chronically exposed to carbon monoxide intoxication. It seems that AgNOR may be used for this purpose.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
