Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Urinary Micro-RNAs As Biomarkers of Urological Cancers: A Systematic Review

Version 1 : Received: 26 May 2023 / Approved: 29 May 2023 / Online: 29 May 2023 (05:15:04 CEST)

A peer-reviewed article of this Preprint also exists.

Aveta, A.; Cilio, S.; Contieri, R.; Spena, G.; Napolitano, L.; Manfredi, C.; Franco, A.; Crocerossa, F.; Cerrato, C.; Ferro, M.; Del Giudice, F.; Verze, P.; Lasorsa, F.; Salonia, A.; Nair, R.; Walz, J.; Lucarelli, G.; Pandolfo, S.D. Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review. Int. J. Mol. Sci. 2023, 24, 10846. Aveta, A.; Cilio, S.; Contieri, R.; Spena, G.; Napolitano, L.; Manfredi, C.; Franco, A.; Crocerossa, F.; Cerrato, C.; Ferro, M.; Del Giudice, F.; Verze, P.; Lasorsa, F.; Salonia, A.; Nair, R.; Walz, J.; Lucarelli, G.; Pandolfo, S.D. Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review. Int. J. Mol. Sci. 2023, 24, 10846.

Abstract

Background: Micro-RNAs (miRNA) are emerging as biomarkers in the detection and prognosis of cancers due to their inherent stability and resilience. Methods: To summarize evidence regarding urinary miRNA (umiRNAs) role in the detection, prognosis and therapeutic management of urological cancers, we performed a systematic review of the most important scientific databases using the following keywords: (urinary mir-na)AND(prostate cancer); (urinary mirna)AND(bladder cancer); (urinary mirna)AND(renal cancer); (urinary mirna)AND(testicular cancer); (urinary mirna)AND(urothelial cancer). Results: Of all, 1364 articles were initially selected. Only original studies in the English language on human specimens were considered for inclusion in our systematic review. Thus, a convenient sample of 60 original articles was identified. Urinary miRNA (UmiRNAs) are downregulated in prostate cancers and may serve as potential non-invasive molecular biomarkers. Several umiR-NAs have been identified as diagnostic biomarkers of urothelial carcinoma and bladder cancer (BCa), allowing to discriminate malignant from non-malignant forms of haematuria. UmiRNAs could serve as therapeutic targets or recurrence markers of non-muscle invasive BCa and could predict the aggressivity and prognosis of muscle-invasive BCa. In renal cell carcinoma, miRNAs have been identified as predictors of tumour detection, aggressiveness, and progression to metastasis. Conclusion: umiRNAs could play an important role in the diagnosis, prognosis, and therapy of urological cancers.

Keywords

Micro-RNAs; biomarkers; urological cancers; prostate cancer; bladder cancer; Upper Tract Urothelial Carcinoma; renal cancer

Subject

Medicine and Pharmacology, Urology and Nephrology

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