Mitra, P.; Jana, S.; Roy, S. Insights into the Therapeutic Uses of Plant Derive Phytocompounds on Diabetic. Current Diabetes Reviews 2024, 20, doi:10.2174/0115733998273395231117114600.
Mitra, P.; Jana, S.; Roy, S. Insights into the Therapeutic Uses of Plant Derive Phytocompounds on Diabetic. Current Diabetes Reviews 2024, 20, doi:10.2174/0115733998273395231117114600.
Mitra, P.; Jana, S.; Roy, S. Insights into the Therapeutic Uses of Plant Derive Phytocompounds on Diabetic. Current Diabetes Reviews 2024, 20, doi:10.2174/0115733998273395231117114600.
Mitra, P.; Jana, S.; Roy, S. Insights into the Therapeutic Uses of Plant Derive Phytocompounds on Diabetic. Current Diabetes Reviews 2024, 20, doi:10.2174/0115733998273395231117114600.
Abstract
Diabetic nephropathy (DN), one of the primary consequences of diabetes mellitus, affecting many people worldwide. Diabetes affects yearly 463 million adults globally between the ages of 20 and 79, and is the main cause of death under the age of 60. ROS production rises during hyperglycemia and is crucial to the development of diabetic complications. Advanced glycation end products (AGEs) are produced excessively in a diabetic state and accumulate in the kidney, where they change renal architecture and impair renal function. Another important targeted pathway for the formation of DN includes NF-B, Nrf2, NLRP3, Akt/mTOR, and autophagy. About 40% of individuals with diabetes eventually acquire diabetic kidney disease and end stage renal disease that needs hemodialysis, peritoneal dialysis, or kidney transplantation, to survive. The current state of acceptable therapy for this kidney ailment is limited. The studies revealed that some naturally occurring bioactive substances might shield the kidney by controlling oxidative stress, renal fibrosis, inflammation, and autophagy. In order to provide new potential therapeutic lead bioactive compounds for contemporary drug discovery and clinical management of DN, this review was designed to examine the various mechanistic pathways by which current conventional plants derive phytocompounds that are effective for the control and treatment of DN.
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