Aguilera-Rodríguez, F.R.; Zamora-Perez, A.L.; Gutiérrez-Hernández, R.; Quirarte-Báez, S.M.; Reyes Estrada, C.A.; Ortiz-García, Y.M.; Lazalde-Ramos, B.P. Teratogen Potential Evaluation of the Aqueous and Hydroalcoholic Leaf Extracts of Crataegus oxyacantha in Pregnancy Rats. Plants2023, 12, 2388.
Aguilera-Rodríguez, F.R.; Zamora-Perez, A.L.; Gutiérrez-Hernández, R.; Quirarte-Báez, S.M.; Reyes Estrada, C.A.; Ortiz-García, Y.M.; Lazalde-Ramos, B.P. Teratogen Potential Evaluation of the Aqueous and Hydroalcoholic Leaf Extracts of Crataegus oxyacantha in Pregnancy Rats. Plants 2023, 12, 2388.
Aguilera-Rodríguez, F.R.; Zamora-Perez, A.L.; Gutiérrez-Hernández, R.; Quirarte-Báez, S.M.; Reyes Estrada, C.A.; Ortiz-García, Y.M.; Lazalde-Ramos, B.P. Teratogen Potential Evaluation of the Aqueous and Hydroalcoholic Leaf Extracts of Crataegus oxyacantha in Pregnancy Rats. Plants2023, 12, 2388.
Aguilera-Rodríguez, F.R.; Zamora-Perez, A.L.; Gutiérrez-Hernández, R.; Quirarte-Báez, S.M.; Reyes Estrada, C.A.; Ortiz-García, Y.M.; Lazalde-Ramos, B.P. Teratogen Potential Evaluation of the Aqueous and Hydroalcoholic Leaf Extracts of Crataegus oxyacantha in Pregnancy Rats. Plants 2023, 12, 2388.
Abstract
Crataegus Oxyacantha is used in the treatment of cardiovascular diseases. In related to your biosafety, only in vitro and in vivo genotoxicity of the fruit and the leaf is described, however, the teratogenic potential is unknown. The aim this study was evaluating the transplacental genotoxicity effect of aqueous and hydroalcoholic extract of leaves C. oxyacantha in a rat model and the quantification of malondialdehyde (MDA) in liver. Three different doses of the aqueous and hydroalcoholic extracts of the C. oxyacantha leaf were administered orally (500, 1000 and 2000 mg/kg) to Wistar rats during 5 days through the pregnancy term (16-21 days), sampling in rats were every 24 h during the last 6 days of gestation and only one sample was taken in neonates at birth. A sample of the mother's and neonate's liver was taken for the determination of MDA. The results show that, at the hepatic level, the evaluated doses of extracts C. oxyacantha in pregnant rats and their pups did not show cytotoxicity. However, the aqueous and hydroalcoholic extract generated cytotoxic and genotoxic damage in the short term. On the other hand, only the aqueous extract showed a teratogenic effect. Based on these results, the aqueous and hydroalcoholic extracts of the C. oxyacantha leaf should not be administered during pregnancy.
Medicine and Pharmacology, Pharmacology and Toxicology
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