Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Prevalence and Burden of Comorbidities in Obstructive Sleep Apnea Syndrome

Victoria Sircu
,
Silvia Colesnic
,
Serghei Covantsev
ORCID logo ,
Olga Corlateanu
,
Anna S Sukhotko
,
Cristian Popovici
,
Alexandru Corlateanu
* ORCID logo
Version 1 : Received: 10 May 2023 / Approved: 11 May 2023 / Online: 11 May 2023 (13:47:41 CEST)

A peer-reviewed article of this Preprint also exists.

Sircu, V.; Colesnic, S.-I.; Covantsev, S.; Corlateanu, O.; Sukhotko, A.; Popovici, C.; Corlateanu, A. The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP. Clocks & Sleep 2023, 5, 333-349. Sircu, V.; Colesnic, S.-I.; Covantsev, S.; Corlateanu, O.; Sukhotko, A.; Popovici, C.; Corlateanu, A. The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP. Clocks & Sleep 2023, 5, 333-349.

Abstract

Repeated desaturation of oxyhemoglobin, micro-arousals, which are typical in obstructive sleep apnea syndrome (OSAS), have negative effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction) cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), neuropsychiatric complications and a wide range of malignancies. This in turn has a multilateral effect on familial, occupational and social life, as well as increasing the risk of road traffic accidents or accidents at workplace. Awareness, timely screening and prevention of complications play an important role in the diagnosis and treatment of comorbid conditions. This review focuses on comorbidities in OSAS and the effect of CPAP therapy on their prognosis.

Keywords

OSAS; CPAP; diabetes mellitus; hypertension; ischemic heart disease; stroke; renal failure

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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