Version 1
: Received: 5 May 2023 / Approved: 6 May 2023 / Online: 6 May 2023 (10:40:04 CEST)
How to cite:
Korobova, Z.R.; Arsentieva, N.A.; Totolian, A. Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19. Preprints2023, 2023050420. https://doi.org/10.20944/preprints202305.0420.v1
Korobova, Z.R.; Arsentieva, N.A.; Totolian, A. Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19. Preprints 2023, 2023050420. https://doi.org/10.20944/preprints202305.0420.v1
Korobova, Z.R.; Arsentieva, N.A.; Totolian, A. Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19. Preprints2023, 2023050420. https://doi.org/10.20944/preprints202305.0420.v1
APA Style
Korobova, Z.R., Arsentieva, N.A., & Totolian, A. (2023). Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19. Preprints. https://doi.org/10.20944/preprints202305.0420.v1
Chicago/Turabian Style
Korobova, Z.R., Natalia A. Arsentieva and Areg Totolian. 2023 "Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19" Preprints. https://doi.org/10.20944/preprints202305.0420.v1
Abstract
Macrophage-derived chemokine belongs to the CC subfamily. It is produced by dendritic cells (DCs) and macrophages with or without external stimulation. We have previously shown a statistically significant depletion of MDC/CCL22 concentrations in a number of studies concerning COVID-19. These shifts in concentrations demonstrated stability unrelated to the SARS-CoV-2 genetic variant and remained noticeable even in convalescent patients. In this work, we analyze MDC/CCL22 dynamics in various diseases, including those that manifest with inflammation in lung tissue. In addition, we provide our hypothesis on such a decrease in MDC/CCL22 concentrations in COVID-19. If its secretion by producer cells is unperturbed, then it is possible for viral products to bind to this chemokine and to block its functional activity. There is, however, another possible explanation directly linked to depletion in DC subpopulations and the inhibition of their function. We also discuss MDC/CCL22's role in the immunology of novel coronavirus infection, based on both our own data and other studies.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
