Version 1
: Received: 28 March 2023 / Approved: 30 March 2023 / Online: 30 March 2023 (13:02:47 CEST)
How to cite:
Subramanian, S. Genomic analysis of Carbapenem-resistance conferring genes in Klebsiellapneumoniae. Preprints2023, 2023030532. https://doi.org/10.20944/preprints202303.0532.v1
Subramanian, S. Genomic analysis of Carbapenem-resistance conferring genes in Klebsiella pneumoniae. Preprints 2023, 2023030532. https://doi.org/10.20944/preprints202303.0532.v1
Subramanian, S. Genomic analysis of Carbapenem-resistance conferring genes in Klebsiellapneumoniae. Preprints2023, 2023030532. https://doi.org/10.20944/preprints202303.0532.v1
APA Style
Subramanian, S. (2023). Genomic analysis of Carbapenem-resistance conferring genes in <i>Klebsiella</i><i> </i><i>pneumoniae</i>. Preprints. https://doi.org/10.20944/preprints202303.0532.v1
Chicago/Turabian Style
Subramanian, S. 2023 "Genomic analysis of Carbapenem-resistance conferring genes in <i>Klebsiella</i><i> </i><i>pneumoniae</i>" Preprints. https://doi.org/10.20944/preprints202303.0532.v1
Abstract
Carbapenems are considered for treating Klebsiella pneumoniae and other Enterobacteriaceae infections, especially if they are not susceptible to other generally prescribed antibiotics, i.e., if they show resistance. In such cases, antibiotic activity decreases, and most patients succumb to the infection. A better understanding of the disease pattern and resistance mechanisms could be gained by magnifying the genes that confer resistance to antibiotics. Therefore, studying the genes that confer resistance to carbapenems and any other antibiotics for that matter is indispensable for coming up with improved treatment options. This study included the analyses of co-resistance patterns between resistance genes-between drug classes and within the carbapenem-resistant genes, genomic context analysis of highly expressed carbapenem-resistant genes, and phylogenetic study of OXA-producing genes, plasmid incompatibility identification, and sequence type identification using MLST. The presence of ESBLs, MBLs, and SBLs across the downloaded genomes was studied. SHV-producing genes were found to co-occur with most of the resistant genes belonging to different drug classes. The plasmid incompatibility type IncFIB was found to be common among the highly expressed genes, and most of these genes were flanked by different families of insertion sequence (IS) elements. MLST study suggested that the presence of sequence types ST-11, ST-14, and ST-147 was common in the downloaded set of genomes.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
