Esquirol Caussa, J.; Sánchez Aldeguer, J.; Herrero Vila, E.; Antón Gorostidi, I.; Colomer Giner, M.; Olivé Torralba, A.; Abella Grau, J.M.; Jiménez Herreros, S.; Llobregat Delgado, C. New Therapeutic Applications of Ozenoxacin in Superficial Skin Infections in Geriatric Patients: A Case Series. Preprints2022, 2022110133. https://doi.org/10.20944/preprints202211.0133.v1
APA Style
Esquirol Caussa, J., Sánchez Aldeguer, J., Herrero Vila, E., Antón Gorostidi, I., Colomer Giner, M., Olivé Torralba, A., Abella Grau, J.M., Jiménez Herreros, S., & Llobregat Delgado, C. (2022). New Therapeutic Applications of Ozenoxacin in Superficial Skin Infections in Geriatric Patients: A Case Series. Preprints. https://doi.org/10.20944/preprints202211.0133.v1
Chicago/Turabian Style
Esquirol Caussa, J., Sònia Jiménez Herreros and Carlos Llobregat Delgado. 2022 "New Therapeutic Applications of Ozenoxacin in Superficial Skin Infections in Geriatric Patients: A Case Series" Preprints. https://doi.org/10.20944/preprints202211.0133.v1
Abstract
INTRODUCTION: Superficial cutaneous bacterial infections have a high incidence in geriatric patients. The most implicated pathogens are gram-positive cocci (Staphylococcus aureus, Streptococcus pyogenes) while gram-negative germs are also implicated. Resistances to common topical antibiotics (mupirocin, fusidic acid) require alternatives to gram-positive and gram-negative microorganisms.Ozenoxacin cream for topical use (non-fluorinated bactericidal quinolone), in other countries and with other galenics, is indicated in children older than 6 months and in adults as a treatment of superficial bacterial infections, such as acne. In Spain, ozenoxacin cream is indicated only for non-bullous impetigo; scientific evidence show effectiveness also in other superficial skin bacterial infections.A cases series of clinical use of ozenoxacin in bacterial superficial skin infections in geriatric patients (institutionalized or community dwelling) is presented.METHODS: Multicenter case series (March-August 2022) of bacterial superficial skin infections treated with ozenoxacin cream (10mg/g every 12h, 5days); data from medical records (controls: 1-3-5 days), after obtaining informed consent (use of data and images).RESULTS: Series of 28 patients (mean age: 84,79) from nine nursing homes and one outpatient geriatric service, including acute and subacute/chronic cases.In all cases treatment was ozenoxacin 10mg/g topical cream applied every 12 hours for 5 days according to medical prescription (except for one case in which 3 days were enough for complete healing and another case treated for 10 days).Results showed complete healing in all 20 acute cases and significant clinical improvement in all subacute/chronic cases (with complete healing in one of them). Professionals scored the effectiveness in acute cases as a mean 4.5 points (maximum score: 5, p<.0001) and in subacute/chronic cases as 3.8 points (p=.010).There was no skin irritation or other adverse effects in anyone of the patients, and clinical improvement of pain, itching and other symptoms was observed, suggesting an anti-inflammatory effect. DISCUSSION AND CONCLUSIONS: Our results seem to demonstrate the effectiveness and tolerability of ozenozacin cream in bacterial infections other than non-bullous impetigo. Ozenoxacin cream is indicated only for the treatment of non-bullous impetigo; however, it is also shown to be effective, both in the scientific evidence and in our case series, for other superficial bacterial skin infections, both acute and subacute/chronic, suggesting the opportunity for clinical studies with an experimental design to evaluate the findings of clinical practice and to be able to have a therapeutic alternative to compensate for the complications of the appearance of resistance.
Keywords
skin infection; antibiotics; quinolone; S. aureus; geriatrics
Subject
Medicine and Pharmacology, Dermatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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