Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

May the 4c’s Be with You: An Overview of Complexity-Inspired Frameworks for Analyzing Resting-State Neuroimaging Data

Version 1 : Received: 4 March 2022 / Approved: 7 March 2022 / Online: 7 March 2022 (12:28:13 CET)

How to cite: Hancock, F.; Rosas, F.; Mediano, P.; Luppi, A.; Cabral, J.; Dipasquale, O.; Turkheimer, F. May the 4c’s Be with You: An Overview of Complexity-Inspired Frameworks for Analyzing Resting-State Neuroimaging Data. Preprints 2022, 2022030097 (doi: 10.20944/preprints202203.0097.v1). Hancock, F.; Rosas, F.; Mediano, P.; Luppi, A.; Cabral, J.; Dipasquale, O.; Turkheimer, F. May the 4c’s Be with You: An Overview of Complexity-Inspired Frameworks for Analyzing Resting-State Neuroimaging Data. Preprints 2022, 2022030097 (doi: 10.20944/preprints202203.0097.v1).

Abstract

Competing and complementary models of resting-state brain dynamics contribute to our phenomenological and mechanistic understanding of whole-brain coordination and communication, and provide potential evidence for differential brain functioning associated with normal and pathological behavior. These neuroscientific theories stem from the perspectives of physics, engineering, mathematics, and psychology and create a complicated landscape of domain-specific terminology and meaning, which, when used outside of that domain, may lead to incorrect assumptions and conclusions within the neuroscience community. Here we review and clarify the key concepts of Connectivity, Computation, Criticality, and Coherence — the 4C’s — and outline a potential role for metastability as a common denominator across these propositions. We analyze and synthesize whole-brain neuroimaging research, examined through functional magnetic imaging (fMRI), to demonstrate that complexity science offers a principled and integrated approach to describe, and potentially understand, macroscale spontaneous brain functioning.

Keywords

Complexity; connectivity; computation; criticality; metastability; integrated information

Subject

MEDICINE & PHARMACOLOGY, Behavioral Neuroscience

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