Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Heterologous Vaccination Strategy on Humoral Response against COVID-19 with CoronaVac Plus BNT162b2: A Prospective Cohort Study

Hakan Demirhindi
* ORCID logo ,
Burak Mete
ORCID logo ,
Ferdi Tanir
,
Ertan Kara
ORCID logo ,
Filiz Kibar
,
Salih Cetiner
,
Aslihan Candevir
,
Sukriye Ece Akti
Version 1 : Received: 1 March 2022 / Approved: 2 March 2022 / Online: 2 March 2022 (12:05:03 CET)

A peer-reviewed article of this Preprint also exists.

Demirhindi, H.; Mete, B.; Tanir, F.; Kara, E.; Kibar, F.; Cetiner, S.; Candevir, A.; Akti, S.E. Effect of Heterologous Vaccination Strategy on Humoral Response against COVID-19 with CoronaVac plus BNT162b2: A Prospective Cohort Study. Vaccines 2022, 10, 687. Demirhindi, H.; Mete, B.; Tanir, F.; Kara, E.; Kibar, F.; Cetiner, S.; Candevir, A.; Akti, S.E. Effect of Heterologous Vaccination Strategy on Humoral Response against COVID-19 with CoronaVac plus BNT162b2: A Prospective Cohort Study. Vaccines 2022, 10, 687.

Abstract

This study aimed to evaluate the mixed and homogeneous application of the inactivated SARS-CoV-2 vaccine CoronaVac (CV) and the mRNA vaccine BNT162b2 (BNT). This prospective cohort study included 235 health care workers, who had received two prime shots with CoronaVac. They were divided into three cohorts after the third month: Cohort-I (CV/CV); Cohort-II (CV/CV/CV) and Cohort-III (CV/CV/BNT). Anti-S-RBD-IgG and total an-ti-spike/anti-nucleocapsid-IgG antibody concentrations were examined in vaccinated health workers at the 1st, 3rd and 6th months following the second dose of the vaccination. The mean age of 235 health care workers who participated in the project was 39.51±10.39 (min-max: 22-64). At the end of the 6th month, no antibodies were detected in 16.7% of Cohort-I participants, and anti-S-RDB IgG levels showed a decrease of 60% compared to the levels of the 3rd month. The antibody concentrations of the 6th month were found to have increased by an average of 5.13 times compared to the 3rd-month levels in the Cohort-II and 20.4 times in Cohort-III. The heterologous vaccination strategy “CoronaVac and BNT162b2 regimen” is able to induce a stronger immunity and it will help remove inequalities in the developing world where CoronaVac was the initial prime.

Keywords

COVID-19 vaccines; seroconversion; inactivated SARS-CoV2 vaccine; BNT162 Vaccine; COVID-19 vaccine booster shot; heterologous vaccination; mixed vaccination; vaccination strategy

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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