Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Is Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease

Version 1 : Received: 6 December 2021 / Approved: 8 December 2021 / Online: 8 December 2021 (11:55:16 CET)

How to cite: Sussman, B..L.; Wyckoff, S.N.; Heim, J.; Wilfong, A.A.; Adelson, D.; Kruer, M.C.; Gonzalez, M.J.; Boerwinkle, V.L. Is Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease. Preprints 2021, 2021120119. https://doi.org/10.20944/preprints202112.0119.v1 Sussman, B..L.; Wyckoff, S.N.; Heim, J.; Wilfong, A.A.; Adelson, D.; Kruer, M.C.; Gonzalez, M.J.; Boerwinkle, V.L. Is Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease. Preprints 2021, 2021120119. https://doi.org/10.20944/preprints202112.0119.v1

Abstract

AbstractIn the evolving modern era of neuromodulation for movement disorders in adults and children, much progress has been made recently characterizing the human motor network (MN) with potentially important treatment implications. Herein is a focused review of relevant resting state fMRI functional and effective connectivity of the human motor network across the lifespan in health and disease. The goal is to examine how the transition from static functional to dynamic effective connectivity may be especially informative of network-targeted movement disorder therapies, with hopeful implications for children.Impact StatementWhile functional connectivity has elucidated much MN properties with relation to age, disease, and behavior, effective connectivity has been shown to be useful in MN-informed therapies in adults. Thus, effective connectivity may have potential to impact childhood movement disorder therapies, given the lower to no patient demand.

Keywords

resting state functional MRI; effective connectivity; dystonia; movement disorders; subcortical; basal ganglia

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

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