Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study

Version 1 : Received: 25 May 2021 / Approved: 26 May 2021 / Online: 26 May 2021 (13:31:28 CEST)

A peer-reviewed article of this Preprint also exists.

Byrne, J.; Murphy, C.; Keogh, J.B.; Clifton, P.M. The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study. Int. J. Environ. Res. Public Health 2021, 18, 8169. Byrne, J.; Murphy, C.; Keogh, J.B.; Clifton, P.M. The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study. Int. J. Environ. Res. Public Health 2021, 18, 8169.

Journal reference: Int. J. Environ. Res. Public Health 2021, 18, 8169
DOI: 10.3390/ijerph18158169

Abstract

Evidence supports an association between low magnesium (Mg) intake and coronary heart disease and between Mg intake and endothelial function. The aim of this study was to assess the effect of one week of Mg supplementation on endothelial function, assessed by flow mediated dilatation (FMD). Nineteen healthy men and women completed this cross-over pilot study in which participants were randomised to take an over-the-counter magnesium supplement for one week or to follow their usual diet. Weight, FMD and blood pressure (BP) were taken on completion of each intervention and 24hour urine collections and blood samples were taken to assess compliance. Baseline serum Mg was within normal range for all participants. Urinary Mg and urinary magnesium-creatinine ratio (Mg/Cr) significantly increased between interventions, (p = 0.03, p = 0.005 respectively). No significant differences in FMD or BP were found between the interventions. A significant negative correlation was seen between age and FMD (r = -0.496, p = 0.031). When adjusted for age, saturated fat was negatively associated with FMD (p = 0.045). One week of Mg supplementation did not improve FMD in a healthy population.

Keywords

magnesium; flow mediated dilatation; endothelial function

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