Preprint Review Version 1 This version is not peer-reviewed

Does COVID-19 Take a Breath? The Chinese Current Situation

Version 1 : Received: 12 April 2021 / Approved: 13 April 2021 / Online: 13 April 2021 (13:00:35 CEST)

How to cite: Qadeer, A.; Sohail, M.; Younas, A.; Iqbal, H.; Ullah, A.; Ullah, H.; Razzaq, A.; Menaa, B.; ul Haq, I.; Ahmed, Z.; Rabbi, F.; Khan, N.; Raza, F.; Nawaz, S.; Khan, I.; ul Haque, M.I.; Menaa, F. Does COVID-19 Take a Breath? The Chinese Current Situation. Preprints 2021, 2021040354 (doi: 10.20944/preprints202104.0354.v1). Qadeer, A.; Sohail, M.; Younas, A.; Iqbal, H.; Ullah, A.; Ullah, H.; Razzaq, A.; Menaa, B.; ul Haq, I.; Ahmed, Z.; Rabbi, F.; Khan, N.; Raza, F.; Nawaz, S.; Khan, I.; ul Haque, M.I.; Menaa, F. Does COVID-19 Take a Breath? The Chinese Current Situation. Preprints 2021, 2021040354 (doi: 10.20944/preprints202104.0354.v1).

Abstract

Four new zoonotic coronaviruses outbreak occurred in the past two decades. The first coronavirus outbreak happened in 2003 and was named Severe Acute Respiratory Syndrome Coronavirus-1 (SARS-CoV-1), followed by Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2013, and by Swine Acute Diarrhoea Syndrome (SADS) in 2017. In late December 2019, a patient from Wuhan Seafood Wholesale Market, China, was admitted to Huang's hospital with respiratory distress syndrome (RDS) of apparently unknown etiology, which later was diagnosed with SARS-CoV-2-induced coronavirus disease-19 (COVID-19). SARS-CoV-2 was identified from another clade within the subgenus Sarbecovirus of the genus Betacoronavirus. This new CoV variant showed 96.2% similarity at whole-genome level to bat coronavirus. Based on genetic studies, pangolin, bats, and snakes are suspected to be a possible intermediate host of this virus, but further research is in progress to determine how this virus appeared and what is the exact source of infection. The SARS-CoV-2 outbreak has higher transmissibility, contagiosity and pathogenicity compared to that of SARS-CoV-1 and MERS-CoV. SARS-CoV-2 swiftly spread from continent to continent and is persistently causing a shocking global public health concern albeit the rate of infected cases and mortality is relatively decreasing over time. In this review, we provide an update on the origin, transmissibility, etiology, epidemiology, and evolution of COVID-19. We also highlight the current diagnostics, therapies, and prognostics for SARS-CoV-2. Eventually, we report and provide our humble opinion about the preventive strategies to control the ongoing related pandemic situation at global and individual levels, considering the international public health emergency and possible future epidemics and pandemics.

Subject Areas

SARS-CoV-2; COVID-19; Genetics; Epidemiology; Theranostics; Vaccines and Preventive Infectiology

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