Murphy, C.; Byrne, J.; Keogh, J.B.; Headland, M.L.; Clifton, P.M. The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study. Int. J. Environ. Res. Public Health2021, 18, 5303.
Murphy, C.; Byrne, J.; Keogh, J.B.; Headland, M.L.; Clifton, P.M. The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study. Int. J. Environ. Res. Public Health 2021, 18, 5303.
Murphy, C.; Byrne, J.; Keogh, J.B.; Headland, M.L.; Clifton, P.M. The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study. Int. J. Environ. Res. Public Health2021, 18, 5303.
Murphy, C.; Byrne, J.; Keogh, J.B.; Headland, M.L.; Clifton, P.M. The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study. Int. J. Environ. Res. Public Health 2021, 18, 5303.
Abstract
Magnesium (Mg) deficiency may be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim was to determine the acute effect of an oral Mg supplement compared to control on endothelieal function assessed by flow-mediated-dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9kg/m2) completed this randomised cross-over study. Blood pressure (BP) and FMD were measured and blood samples taken before participants drank 200ml water with or without an over the counter Mg supplement (450mg and 300mg for men and women). Measurements were repeated at 60 and 120 minutes. There was a statistically significant two-way interaction between treatment and time on serum Mg (p = .037). A difference of -0.085mm in FMD was observed 60 minutes post drink in the control group compared to baseline FMD, and no difference was observed in the supplement group compared to baseline. Despite the non-significant interaction between treatment and time on FMD, the difference seen in the control group and the lack of change in the supplement group at 60 minutes post-drink suggests that Mg may attenuate the reduction in FMD post-prandially.
Keywords
magnesium; flow mediated dilatation; endothelial function
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
