Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study

Version 1 : Received: 24 March 2021 / Approved: 25 March 2021 / Online: 25 March 2021 (15:29:51 CET)

A peer-reviewed article of this Preprint also exists.

Murphy, C.; Byrne, J.; Keogh, J.B.; Headland, M.L.; Clifton, P.M. The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study. Int. J. Environ. Res. Public Health 2021, 18, 5303. Murphy, C.; Byrne, J.; Keogh, J.B.; Headland, M.L.; Clifton, P.M. The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study. Int. J. Environ. Res. Public Health 2021, 18, 5303.

Journal reference: Int. J. Environ. Res. Public Health 2021, 18, 5303
DOI: 10.3390/ijerph18105303

Abstract

Magnesium (Mg) deficiency may be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim was to determine the acute effect of an oral Mg supplement compared to control on endothelieal function assessed by flow-mediated-dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9kg/m2) completed this randomised cross-over study. Blood pressure (BP) and FMD were measured and blood samples taken before participants drank 200ml water with or without an over the counter Mg supplement (450mg and 300mg for men and women). Measurements were repeated at 60 and 120 minutes. There was a statistically significant two-way interaction between treatment and time on serum Mg (p = .037). A difference of -0.085mm in FMD was observed 60 minutes post drink in the control group compared to baseline FMD, and no difference was observed in the supplement group compared to baseline. Despite the non-significant interaction between treatment and time on FMD, the difference seen in the control group and the lack of change in the supplement group at 60 minutes post-drink suggests that Mg may attenuate the reduction in FMD post-prandially.

Keywords

magnesium; flow mediated dilatation; endothelial function

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