Version 1
: Received: 22 April 2020 / Approved: 24 April 2020 / Online: 24 April 2020 (14:03:31 CEST)
Version 2
: Received: 26 July 2020 / Approved: 27 July 2020 / Online: 27 July 2020 (05:59:51 CEST)
Lansiaux, Édouard*; Pébaÿ, Philippe P. PhD†; Picard, Jean-Laurent MSc‡; Forget, Joachim MD, PhD§ Meta-analysis: COVID-19 Disease Severity Correlates With Smoking Status, Clinical Pulmonary Medicine: July 2020 - Volume 27 - Issue 4 - p 99-104
doi: 10.1097/CPM.0000000000000364
Lansiaux, Édouard*; Pébaÿ, Philippe P. PhD†; Picard, Jean-Laurent MSc‡; Forget, Joachim MD, PhD§ Meta-analysis: COVID-19 Disease Severity Correlates With Smoking Status, Clinical Pulmonary Medicine: July 2020 - Volume 27 - Issue 4 - p 99-104
doi: 10.1097/CPM.0000000000000364
Lansiaux, Édouard*; Pébaÿ, Philippe P. PhD†; Picard, Jean-Laurent MSc‡; Forget, Joachim MD, PhD§ Meta-analysis: COVID-19 Disease Severity Correlates With Smoking Status, Clinical Pulmonary Medicine: July 2020 - Volume 27 - Issue 4 - p 99-104
doi: 10.1097/CPM.0000000000000364
Lansiaux, Édouard*; Pébaÿ, Philippe P. PhD†; Picard, Jean-Laurent MSc‡; Forget, Joachim MD, PhD§ Meta-analysis: COVID-19 Disease Severity Correlates With Smoking Status, Clinical Pulmonary Medicine: July 2020 - Volume 27 - Issue 4 - p 99-104
doi: 10.1097/CPM.0000000000000364
Abstract
The novel COVID-19 disease is a contagious acute respiratory infectious disease whose causative agent has been demonstrated to be a new virus of the coronavirus family, SARS- CoV-2. Multiple studies have already reported that risk factors for severe disease include older age and the presence of at least one of several underlying health conditions. However, a recent physiopathological report and the French COVID-19 scientific council have postulated a protective effect of tobacco smoking. Thanks to a meta-analysis, we have been able to demonstrate the statistical significance in this regard of twelve series from China, France and in the US, reporting three different smoking status (current smoker,former smoker, with a smoking history) as well as disease severity (with respectively odds-ratio of 1.78 [1.08-3.10], 4.60 [3.13-7.17], 2.74 [0.63-5.89]). Subsequently and using a Bayesian approach we have established that past, and present smoking is associated with more severe COVID-19 outcomes. Finally, we refute claims linking general population smoking status (N=O(10^8) or O(10^9)) to much smaller disease course series (N=O(10^4)). The latter point in particular is presented to stimulate academic discussion, and must be further investigated by well-designed studies.
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Edouard Lansiaux
Commenter's Conflict of Interests: Author