Preprint Review Version 1 This version not peer reviewed

Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission

Version 1 : Received: 6 December 2017 / Approved: 7 December 2017 / Online: 7 December 2017 (07:39:49 CET)

How to cite: Vannucchi, M.G.; Evangelista, S. Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission. Preprints 2017, 2017120042 (doi: 10.20944/preprints201712.0042.v1). Vannucchi, M.G.; Evangelista, S. Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission. Preprints 2017, 2017120042 (doi: 10.20944/preprints201712.0042.v1).

Abstract

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diseases in humans. It is characterized by visceral pain and/or discomfort, hypersensitivity and abnormal motor responses along with change in gut habits. Although the etio-pathogenesis of IBS is only partially understood, a main role has been attributed to psychosocial stress of different origin. Animals models such as neonatal maternal separation, water avoidance stress and wrap restraint stress have been developed as psychosocial stressors in the attempt to reproduce the IBS symptomatology and identify the cellular mechanisms responsible for the disease. The study of these models has led to the production of drugs potentially useful for IBS treatment. This review intends to give an overview on the results obtained with the animal models; to emphasize the role of the enteric nervous system in IBS appearance and evolution and as a possible target of drug therapies.

Subject Areas

corticotropin releasing factor; irritable bowel syndrome (IBS); maternal separation (MS); neurotransmitters; pain; psychosocial stress; visceral hyperalgesia; water avoidance stress (WAS); wrap restrain stress (WRS)

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