PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?
Version 1
: Received: 18 May 2024 / Approved: 20 May 2024 / Online: 20 May 2024 (14:39:36 CEST)
How to cite:
Pietruszyńska-Reszetarska, A.; Pietruszyński, R.; Irzmański, R. The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?. Preprints2024, 2024051287. https://doi.org/10.20944/preprints202405.1287.v1
Pietruszyńska-Reszetarska, A.; Pietruszyński, R.; Irzmański, R. The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?. Preprints 2024, 2024051287. https://doi.org/10.20944/preprints202405.1287.v1
Pietruszyńska-Reszetarska, A.; Pietruszyński, R.; Irzmański, R. The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?. Preprints2024, 2024051287. https://doi.org/10.20944/preprints202405.1287.v1
APA Style
Pietruszyńska-Reszetarska, A., Pietruszyński, R., & Irzmański, R. (2024). The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?. Preprints. https://doi.org/10.20944/preprints202405.1287.v1
Chicago/Turabian Style
Pietruszyńska-Reszetarska, A., Robert Pietruszyński and Robert Irzmański. 2024 "The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?" Preprints. https://doi.org/10.20944/preprints202405.1287.v1
Abstract
Methylation is a biochemical process involving the addition of a methyl group (-CH3) to various chemical compounds. It plays a crucial role in maintaining the homeostasis of the endothelium, which lines the interior surface of blood vessels and has been linked, among other conditions, to coronary artery disease (CAD). Despite significant progress in CAD diagnosis and treatment, intensive research continues into genotypic and phenotypic CAD biomarkers. This review explores the significance of the methylation pathway and folate metabolism in CAD pathogenesis, with a focus on endothelial dysfunction resulting from deficiency in the active form of folate (5-MTHF). We discuss emerging areas of research into CAD biomarkers and factors influencing the methylation process. By highlighting genetically determined methylation disorders, particularly the MTHFR polymorphism, we propose the potential use of the active form of folic acid (5-MTHF) as a novel CAD biomarker and personalized pharmaceutical for selected patient groups. Our aim is to improve the identification of individuals at high risk of CAD and enhance their prognosis.
Keywords
Methylation; Folate; 5-MTHF; Coronary artery disease; biomarker, personalized medicine
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
