Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF

Wolfgang A. Goetz; Jiang Yao; Michael Brener; Rishi Puri; Martin Swaans; Simon Schopka; Sigrid Wiesner; Marcus Creutzenberger; Horst Sievert; Ghassan S. Kassab

doi:10.20944/preprints202405.1155.v1

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preprints.org > biology and life sciences > anatomy and physiology > doi: 10.20944/preprints202405.1155.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF

Marcus Creutzenberger

Horst Sievert

Ghassan S. Kassab

Version 1 : Received: 16 May 2024 / Approved: 17 May 2024 / Online: 17 May 2024 (09:02:23 CEST)

How to cite: Goetz, W. A.; Yao, J.; Brener, M.; Puri, R.; Swaans, M.; Schopka, S.; Wiesner, S.; Creutzenberger, M.; Sievert, H.; Kassab, G. S. Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF. Preprints 2024, 2024051155. https://doi.org/10.20944/preprints202405.1155.v1 Goetz, W. A.; Yao, J.; Brener, M.; Puri, R.; Swaans, M.; Schopka, S.; Wiesner, S.; Creutzenberger, M.; Sievert, H.; Kassab, G. S. Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF. Preprints 2024, 2024051155. https://doi.org/10.20944/preprints202405.1155.v1

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MDPI and ACS Style

Goetz, W. A.; Yao, J.; Brener, M.; Puri, R.; Swaans, M.; Schopka, S.; Wiesner, S.; Creutzenberger, M.; Sievert, H.; Kassab, G. S. Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF. Preprints 2024, 2024051155. https://doi.org/10.20944/preprints202405.1155.v1

APA Style

Goetz, W. A., Yao, J., Brener, M., Puri, R., Swaans, M., Schopka, S., Wiesner, S., Creutzenberger, M., Sievert, H., & Kassab, G. S. (2024). Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF. Preprints. https://doi.org/10.20944/preprints202405.1155.v1

Chicago/Turabian Style

Goetz, W. A., Horst Sievert and Ghassan S. Kassab. 2024 "Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF" Preprints. https://doi.org/10.20944/preprints202405.1155.v1

Abstract

Left ventricular (LV) longitudinal function is mechanically coupled to the elasticity of the ascending aorta (AA). The pathophysiologic link between stiff AA and reduced longitudinal strain and subsequent deterioration in longitudinal LV systolic function is likely relevant in heart failure with preserved ejection fraction (HFpEF). A proposed therapeutic effect of freeing the LV apex and allowing for LV inverse longitudinal shortening was studied in-silico utilizing Living Left Heart Human Model (Dassault Systémes Simulia Corporation). LV function was evaluated in a model with A) Elastic AA; B) Stiff AA; and C) Stiff AA with free LV apex. The cardiac model simulation demonstrated that freeing the apex caused inverse LV longitudinal shortening that can abolish the deleterious mechanical effect of a stiff AA on LV function. A stiff AA and impairment of LV longitudinal strain are common in patients HFpEF. The hypothesis-generating model strongly suggests that freeing the apex and inverse longitudinal shortening may improve LV function in HFpEF patients with a stiff AA.

Keywords

finite element method; computational simulation; aortic stiffness; atrio-ventricular plane displacement; ventricular strain; ventricular function; left ventricular apex; inverse left ventricular shortening; HFpEF

Subject

Biology and Life Sciences, Anatomy and Physiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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